Presynaptic release‐regulating NMDA receptors in isolated nerve terminals: A narrative review,British Journal of Pharmacology

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Presynaptic release‐regulating NMDA receptors in isolated nerve terminals: A narrative review
British Journal of Pharmacology ( IF 6.8 ) Pub Date : 2020-12-21 , DOI: 10.1111/bph.15349
Anna Pittaluga _{1,

2}

Affiliation

The existence of presynaptic, release‐regulating NMDA receptors in the CNS has been long matter of discussion. Most of the reviews dedicated to support this conclusion have preferentially focussed on the results from electrophysiological studies, paying little or no attention to the data obtained with purified synaptosomes, even though this experimental approach has been recognized as providing reliable information concerning the presence and the role of presynaptic release‐regulating receptors in the CNS. To fill the gap, this review is dedicated to summarising the results from studies with synaptosomes published during the last 40 years, which support the existence of auto and hetero NMDA receptors controlling the release of transmitters such as glutamate, GABA, dopamine, noradrenaline, 5‐HT, acetylcholine and peptides, in the CNS of mammals. The review also deals with the results from immunochemical studies in isolated nerve endings that confirm the functional observations.

中文翻译：

孤立神经末梢突触前释放调节 NMDA 受体：叙述性综述

中枢神经系统中突触前、释放调节的 NMDA 受体的存在一直是讨论的话题。大多数致力于支持这一结论的评论都优先关注电生理研究的结果，很少或根本不关注用纯化的突触体获得的数据，尽管这种实验方法已被认为提供了关于存在和作用的可靠信息中枢神经系统突触前释放调节受体。为了填补这一空白，本综述致力于总结过去 40 年来发表的突触体研究结果，这些结果支持控制谷氨酸、GABA、多巴胺、去甲肾上腺素等递质释放的自体和异源 NMDA 受体的存在，5哺乳动物中枢神经系统中的-HT、乙酰胆碱和肽。

更新日期：2021-02-11

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