Abstract: Gambogic acid (GA), a kind of dry resin secreted by the Garcinia hanburyi tree, is a natural active ingredient with various biological activities, such as anti-cancer, anti-inflammatory, antioxidant, anti-bacterial effects, etc. An increasing amount of evidence indicates that GA has obvious anti-cancer effects via various molecular mechanisms, including the induction of apoptosis, autophagy, cell cycle arrest and the inhibition of invasion, metastasis, angiogenesis. In order to improve the efficacy in cancer treatment, nanometer drug delivery systems have been employed to load GA and form micelles, nanoparticles, nanofibers, and so on. In this review, we aim to offer a summary of chemical structure and properties, anti-cancer activities, drug delivery systems and combination therapy of GA, which might provide a reference to promote the development and clinical application of GA.

Keywords: gambogic acid, anti-cancer activities, drug delivery systems, combination therapy


中文翻译：

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藤黄酸作为癌症治疗候选药物：综述


摘要：藤黄酸（GA）是藤黄树分泌的一种干燥树脂，是一种天然活性成分，具有抗癌、抗炎、抗氧化、抗菌等多种生物活性。越来越多的证据表明，GA通过多种分子机制具有明显的抗癌作用，包括诱导细胞凋亡、自噬、细胞周期阻滞以及抑制侵袭、转移、血管生成等。为了提高癌症治疗的疗效，纳米药物递送系统被用来负载GA并形成胶束、纳米粒子、纳米纤维等。本综述旨在对GA的化学结构和性质、抗癌活性、给药系统和联合治疗等方面进行综述，为促进GA的开发和临床应用提供参考。


关键词：藤黄酸，抗癌活性，药物输送系统，联合治疗