Polysaccharide-Based Supramolecular Hydrogel for Efficiently Treating Bacterial Infection and Enhancing Wound Healing,Biomacromolecules

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Polysaccharide-Based Supramolecular Hydrogel for Efficiently Treating Bacterial Infection and Enhancing Wound Healing
Biomacromolecules ( IF 5.5 ) Pub Date : 2020-12-21 , DOI: 10.1021/acs.biomac.0c01401
Jing Wang _{1,

2} , Li Feng ₂ , Qilin Yu ₃ , Yong Chen _{1,

2} , Yu Liu ₂

Affiliation

Nowadays, the rapid emergence of antibiotic-resistant pathogens has become a serious threat to human health. As an effective antimicrobial therapy, supramolecular materials show unprecedented advantages because of their flexible and adjustable interactions with biological molecules. Supramolecular hydrogels are now widely applied in biomedical fields because of their outstanding biocompatibility, high water content, easy preparation, and unique functions. Herein, we conveniently prepared a stable supramolecular hydrogel by simply mixing β-cyclodextrin-modified chitosan (CS–CD) with AgNO₃ in a basic environment. The obtained supramolecular hydrogel, which is positively charged and possesses numerous β-cyclodextrin cavities, could efficiently load anionic drug diclofenac sodium (DS) through the electrostatic interaction and host–guest inclusion. Significantly, the biological experiments demonstrated that this supramolecular hydrogel exhibited a high antibacterial effect and good ability of promoting wound healing owing to the cooperative contribution of CS, Ag⁺, and DS.

中文翻译：

基于多糖的超分子水凝胶可有效治疗细菌感染并增强伤口愈合

如今，抗生素抗性病原体的迅速出现已成为对人类健康的严重威胁。作为一种有效的抗菌疗法，超分子材料因其与生物分子的灵活且可调节的相互作用而显示出空前的优势。超分子水凝胶因其出色的生物相容性，高水含量，易于制备和独特功能而被广泛应用于生物医学领域。在这里，我们只需将β-环糊精修饰的壳聚糖（CS-CD）与AgNO ₃混合即可方便地制备稳定的超分子水凝胶。在基本环境中。所获得的超分子水凝胶是带正电的，并具有许多β-环糊精腔，可以通过静电相互作用和主客体包涵体有效负载阴离子药物双氯芬酸钠（DS）。重要的是，生物学实验表明，由于CS，Ag ⁺和DS的共同作用，这种超分子水凝胶具有很高的抗菌作用和促进伤口愈合的良好能力。

更新日期：2021-02-08

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