Stimuli‐Responsive Nanomaterials for Smart Tumor‐Specific Phototherapeutics,ChemMedChem

当前位置： X-MOL 学术 › ChemMedChem › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Stimuli‐Responsive Nanomaterials for Smart Tumor‐Specific Phototherapeutics
ChemMedChem ( IF 3.6 ) Pub Date : 2020-12-20 , DOI: 10.1002/cmdc.202000831
Bo Zhou ₁ , Zhengxi Guo ₁ , Zhaoxin Lin ₁ , Bang-Ping Jiang ₁ , Xing-Can Shen ₁

Affiliation

Phototherapy, a type of photoresponsive regulation of biological activities, together with additional stimuli‐responsive features, offers significant potential for enhancing the precision and eﬃcacy of cancer treatments. To achieve tumor‐specific therapeutics, numerous studies have focused on the development of smart phototherapeutic nanomaterials (PNMs) that can respond to endogenous pathological characteristics (e. g., mild acidity, the overproduction of glutathione, the overproduction of hydrogen peroxide, the overexpression of specific surface receptors, etc.) present in the tumor and/or exogenous stimuli. Such responsiveness can effectively improve the physicochemical properties, cellular uptake, tumor‐targeting performance, and pharmacokinetic profile of PNMs. Herein, we will systematically discuss recent advances in this field. Moreover, potential challenges and future directions in the development of stimuli‐responsive PNMs are also presented to support the development of this emerging cutting‐edge research area.

中文翻译：

用于智能肿瘤特异性光疗法的刺激响应纳米材料

光疗是一种对生物活动的光响应调节，加上额外的刺激响应特征，为提高癌症治疗的精确度和有效性提供了巨大的潜力。为了实现肿瘤特异性治疗，许多研究都集中在智能光治疗纳米材料 (PNM) 的开发上，该材料可以响应内源性病理特征（例如，弱酸性、谷胱甘肽的过度产生、过氧化氢的过度产生、特定表面的过度表达）。受体等）存在于肿瘤和/或外源刺激中。这种反应性可以有效改善 PNM 的理化特性、细胞摄取、肿瘤靶向性能和药代动力学特征。在此，我们将系统地讨论该领域的最新进展。而且，

更新日期：2020-12-20

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南