NADH Regeneration: A Case Study of Pt-Catalyzed NAD+ Reduction with H2,ACS Catalysis

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NADH Regeneration: A Case Study of Pt-Catalyzed NAD+ Reduction with H2
ACS Catalysis ( IF 11.3 ) Pub Date : 2020-12-18 , DOI: 10.1021/acscatal.0c04360
Tony Saba ₁ , Jianwei Li _{1,

2} , Joseph W. H. Burnett ₁ , Russell F. Howe ₃ , Panagiotis N. Kechagiopoulos ₁ , Xiaodong Wang _{1,

2}

Affiliation

This study shows the importance of resolving catalytic performance in the regeneration of the reduced form of nicotinamide adenine dinucleotide (NADH) through activity measurements based on NAD⁺ conversion and the closure of mass balance via byproduct quantification. This approach is applied to assess the performance of supported platinum catalysts with varying points of zero charge, utilizing H₂ as a reductant. It was found that Pt/SiO₂, which exhibits a net negative charge under the reaction conditions, outperforms the neutral Pt/C and positively charged Pt/MgO because of the favorable electrostatic attraction between the catalyst surface and positively charged (+1) nicotinamide ring. NMR spectroscopy identifies side-products formed during NAD⁺ hydrogenation.

中文翻译：

NADH再生：以Pt催化的NAD ⁺ H ₂还原为例

这项研究显示了通过基于NAD ⁺转化的活性测量以及通过副产物定量关闭质量平衡来解决还原型烟酰胺腺嘌呤二核苷酸（NADH）再生中催化性能的重要性。该方法适用于利用H ₂作为还原剂评估零电荷变化点的负载型铂催化剂的性能。发现在反应条件下表现出净负电荷的Pt / SiO ₂优于中性Pt / C和带正电的Pt / MgO，因为在催化剂表面和带正电的（+1）烟酰胺之间具有良好的静电吸引环。NMR光谱可识别NAD ⁺期间形成的副产物氢化。

更新日期：2021-01-01

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