ABSTRACT

The chemical composition of essential oils of Artemisia vulgaris L. plants collected in Lithuanian has been reported. The oils were obtained by hydro-distillation from air-dried aerial parts. Up to 75 compounds (an average 88.7– 99.3% of the total oil content) were identified by GC−MS and GC (FID). Germacrene D (10.6 ± 2.5 – 30.5 ± 2.0%) was revealed as the first principal constituent in the investigated oils. To the best of our knowledge, mugwort essential oils rich in germacrene D are quite rare. 1,8-Cineole (6.9 ± 1.9 − 9.8 ± 1.1%, in 4 oils), β-pinene (6.7 ± 1.2 and 8.4 ± 2.3%), sabinene (8.5 ± 1.8%), cis-thujone (12.9 ± 2.5%), β-caryophyllene (5.5 ± 1.3 − 16.7 ± 4.2%, in 5 samples), caryophyllene oxide (6.4 ± 1.1 − 9.3 ± 1.3%, in 4 oils), α-humulene (5.5 ± 1.5%) and davanone (6.5 ± 2.5%) were found to be the second or third major compounds. The toxic activity of five mugwort essential oil samples was evaluated using a brine shrimp (Artemia sp.) bioassay. LC₅₀ mean values (10.25–19.11 µg/mL) revealed that the oils containing appreciable amounts of germacrene D were notably toxic.

摘要

据报道，在立陶宛收集到的艾蒿植物精油的化学成分。这些油是通过从空气干燥的空中零件进行加氢蒸馏而获得的。通过GC-MS和GC（FID）鉴定出多达75种化合物（平均占总油含量的88.7–99.3％）。Germacrene D（10.6±2.5 – 30.5±2.0％）被揭示为所研究油类的第一主要成分。据我们所知，富含胚芽烯D的艾蒿精油非常罕见。1,8-Cineole（6.9±1.9-9.8±1.1％，在4种油中），β -pine烯（6.7±1.2和8.4±2.3％）、,烯（8.5±1.8％），顺式-丁酮（12.9±2.5％） ），β-石竹烯（5.5±1.3-16.7±4.2％，在5个样品中），石竹烯氧化物（6.4± 1.1-9.3 ±1.3％，在4种油中），α-腐殖烯（5.5±1.5％）和达瓦农（6.5±2.5％）被发现是第二或第三主要化合物。使用盐水虾（Artemia sp。）生物测定法评估了五个艾蒿精油样品的毒性。LC ₅₀平均值（10.25–19.11 µg / mL）表明，含有相当数量的germ啶D的油具有明显的毒性。