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Asymmetric Synthesis of Chiral Amino Carboxylic‐Phosphonic Acid Derivatives
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-12-16 , DOI: 10.1002/adsc.202001345
Hao‐Qiang Cao 1 , Jun‐Kuan Li 1 , Fa‐Guang Zhang 1, 2 , Dominique Cahard 3 , Jun‐An Ma 1, 2
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-12-16 , DOI: 10.1002/adsc.202001345
Hao‐Qiang Cao 1 , Jun‐Kuan Li 1 , Fa‐Guang Zhang 1, 2 , Dominique Cahard 3 , Jun‐An Ma 1, 2
Affiliation
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Chiral amino acids featuring a phosphonate pendant arm are an important type of biologically active scaffold. Here in this review, we comprehensively summarize the modern synthetic methods towards asymmetric construction of chiral amino carboxylic‐phosphonic acid derivatives. The main streams of such interesting compounds include phosphono‐containing α‐, β‐, and γ‐amino acid derivatives, amino acid fluorophosphonate derivatives, amino acid cyclopropanylphosphonate derivatives, and bisphosphono‐amino acid derivatives. Chiral resolution protocols, chiral auxiliary‐directed syntheses, and valorization of the pool of abundant chiral amino acid resources remain contemporary concerns, and meanwhile catalytic enantioselective synthesis has also emerged as a potent strategy as demonstrated by the latest advances.
中文翻译:
手性氨基羧酸-膦酸衍生物的不对称合成
具有膦酸酯侧链的手性氨基酸是一种重要的生物活性支架。在本文中,我们全面总结了针对手性氨基羧酸-膦酸衍生物不对称构建的现代合成方法。这些有趣的化合物的主要来源包括含膦酰基的α-,β-和γ-氨基酸衍生物,氨基酸氟代膦酸酯衍生物,氨基酸环丙烷基膦酸酯衍生物和双膦酰基氨基酸衍生物。手性拆分方案,手性辅助合成方法以及丰富的手性氨基酸资源库的增值仍然是当代关注的问题,与此同时,催化对映选择性合成也已成为一种有效的策略,最新进展表明了这一点。
更新日期:2021-02-02
中文翻译:
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手性氨基羧酸-膦酸衍生物的不对称合成
具有膦酸酯侧链的手性氨基酸是一种重要的生物活性支架。在本文中,我们全面总结了针对手性氨基羧酸-膦酸衍生物不对称构建的现代合成方法。这些有趣的化合物的主要来源包括含膦酰基的α-,β-和γ-氨基酸衍生物,氨基酸氟代膦酸酯衍生物,氨基酸环丙烷基膦酸酯衍生物和双膦酰基氨基酸衍生物。手性拆分方案,手性辅助合成方法以及丰富的手性氨基酸资源库的增值仍然是当代关注的问题,与此同时,催化对映选择性合成也已成为一种有效的策略,最新进展表明了这一点。