Assembly of Water‐soluble AIE‐active Fluorescent Organic Nanoparticles for Ratiometric Detection of Hypochlorite in Living Cells,Chemistry - An Asian Journal

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Assembly of Water‐soluble AIE‐active Fluorescent Organic Nanoparticles for Ratiometric Detection of Hypochlorite in Living Cells
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2020-12-16 , DOI: 10.1002/asia.202001325
Yi-Chen Liu ₁ , Wei Du ₁ , Guang-Jian Liu ₁ , Wei Zhou ₁ , Xiao-Jie Gao ₁ , Guo-Wen Xing ₁

Affiliation

Hypochlorous acid (HOCl) plays a crucial role in many physiological processes and is widely used as bleach, deodorant and fungicide. In this work, we designed an amphiphilic hydrazone fluorescent molecule THG‐1 containing hydrophilic sugar units and hydrophobic tetraphenylethylene unit for ratiometric detection of HOCl with high sensitivity and excellent selectivity based on HOCl‐triggered hydrolyzation reaction and aggregation‐induced emission (AIE) effect. The detection mechanism was verified by liquid chromatograph mass spectrometry experiments and scanning electron microscope (SEM) tests. Contrast experiments revealed that the numbers of lactose unit and hydrazone linker were essential for assembly of THG‐1 and detection of HOCl. In addition, THG‐1 was successfully used for imaging of exogenous and endogenous HOCl in living cells.

中文翻译：

水溶性AIE活性荧光有机纳米粒子的组装，用于按比例检测活细胞中的次氯酸盐

次氯酸（HOCl）在许多生理过程中起着至关重要的作用，被广泛用作漂白剂，除臭剂和杀真菌剂。在这项工作中，我们基于HOCl触发的水解反应和聚集诱导发射（AIE）效果，设计了一种包含亲水性糖单元和疏水性四苯基乙烯单元的两亲hydr荧光分子THG-1，以高灵敏度和出色的选择性检测HOCl。通过液相色谱质谱实验和扫描电子显微镜（SEM）测试验证了检测机理。对比实验表明，乳糖单元和连接体的数目对于THG-1的组装和HOCl的检测至关重要。此外，THG-1 已成功用于活细胞中外源性和内源性HOCl的成像。

更新日期：2021-02-15

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