A new three-component strategy for the copper-catalyzed annulation–cyanotrifluoromethylation of easily available 1,7-enynes with Togni’s reagent and TMSCN is developed. The reaction proceeds smoothly under mild conditions, providing a rapid and concise access to a wide range of stereodefined (Z)-3,4-dihydronaphthalen-1(2H)-ones with a quaternary carbon center in generally good yields. The protocol enjoys wide substrate scope regarding 1,7-enynes, high functional group tolerance and complete stereoselectivity.

中文翻译：

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通过铜催化的1,7-烯炔的氰基-氰基三氟甲基化生成立体定义的（Z）-3,4-二氢萘-1（2 H）-

开发了一种新的由三部分组成的铜催化环化策略，即使用Togni试剂和TMSCN容易获得的1,7-烯炔的氰基三氟甲基化。该反应在温和的条件下平稳进行，可以快速，简捷地获得具有季碳中心的各种立体定义的（Z）-3,4-二氢萘-1（2H）-一，收率通常很高。该协议享有1,7-烯炔的广泛底物范围，高官能团耐受性和完全立体选择性。