A case series of Diffuse Glioneuronal Tumours with Oligodendroglioma‐like features and Nuclear Clusters (DGONC),Neuropathology and Applied Neurobiology

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A case series of Diffuse Glioneuronal Tumours with Oligodendroglioma‐like features and Nuclear Clusters (DGONC)
Neuropathology and Applied Neurobiology ( IF 4.0 ) Pub Date : 2021-01-12 , DOI: 10.1111/nan.12680
Jessica C Pickles _{1,

2} , Kshitij Mankad ₃ , Miren Aizpurua ₄ , Simon Ml Paine ₅ , Leslie R Bridges ₆ , Fernando Carceller ₇ , Elwira Szychot ₇ , Mark Walker ₈ , Amy R Fairchild _{1,

2} , Talisa Mistry ₂ , Olumide Ogunbiyi ₂ , Alice Rolland ₉ , Thomas J Stone _{1,

2} , Carryl Dryden ₁₀ , Dilys Addy ₁₀ , Elisa Garimberti ₁₀ , Jane Chalker ₁₀ , Felix Sahm _{11,

12,

13} , David Tw Jones _{11,

14} , Darren Hargrave _{1,

15} , Thomas S Jacques _{1,

2}

Affiliation

Developmental Biology and Cancer (DBC) Research & Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK.
Department of Histopathology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.
Department of Radiology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.
Department of Clinical, Neuropathology King's College Hospital NHS Foundation Trust, London, UK.
Queen's Medical Centre Campus, Nottingham University Hospitals NHS Trust, Nottingham, UK.
Department of Neuropathology, St George's Hospital NHS Trust, London, UK.
Children and Young People's Unit, The Royal Marsden NHS Foundation Trust, Surrey, UK.
Cellular Pathology, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Département de Neurochirurgie, Centre Hospitalier Universitaire Montpellier, France.
Specialist Integrated Haematology and Malignancy Diagnostic Service-Acquired Genomics, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Hopp Children's Cancer Center Heidelberg (KiTZ, University Hospital Heidelberg, Heidelberg, Germany.
Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.
Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK, German Cancer Research Center (DKFZ, Heidelberg, Germany.
Pediatric Glioma Research Group, German Cancer Research Center (DKFZ, Heidelberg, Germany.
Department of Paediatric Oncology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.

We read with interest Deng et al.'s recent manuscript concerning a newly molecularly defined glioneuronal CNS tumour entity, termed diffuse glioneuronal tumour with oligodendroglioma-like features and nuclear clusters (DGONC)(1). DGONCs were identified by a distinctive methylation profile that segregated away from previously recognised molecular groups of CNS tumours. On further review, the authors describe DGONCs as a novel glioneuronal tumour with key neuropathological features including oligodendroglioma-like perinuclear halos and nuclear clusters.

中文翻译：

具有少突胶质细胞瘤样特征和核簇（DGONC）的弥漫性胶质神经元肿瘤病例系列

我们感兴趣地阅读了 Deng 等人最近关于一种新的分子定义的胶质神经元 CNS 肿瘤实体的手稿，称为具有少突胶质细胞瘤样特征和核簇 (DGONC)(1) 的弥漫性胶质神经元肿瘤。DGONCs 是通过一种独特的甲基化谱来鉴定的，该谱与先前识别的 CNS 肿瘤分子组分离。在进一步回顾中，作者将 DGONCs 描述为一种具有关键神经病理学特征的新型胶质神经元肿瘤，包括少突胶质细胞瘤样核周晕和核簇。

更新日期：2021-01-12

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