Palladium catalyzed 8-aminoimidazo[1,2-a]pyridine (AIP) directed selective β-C(sp2)–H arylation,Organic & Biomolecular Chemistry

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Palladium catalyzed 8-aminoimidazo[1,2-a]pyridine (AIP) directed selective β-C(sp2)–H arylation
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-12-8 , DOI: 10.1039/d0ob02134b
Biswajit Mondal _{1,

2,

3,

4,

5} , Prasanjit Ghosh _{3,

4,

5,

6} , MrinalKanti Kundu _{1,

2,

3} , Tapas Kumar Das _{1,

2,

3,

4,

5} , Sajal Das _{3,

4,

5,

6}

Affiliation

Palladium catalyzed arylation of the inert β-C(sp²)–H bond of carboxylic acid derivatives is reported herein for the first time utilizing 8-aminoimidazo[1,2-a]pyridine (AIP) as an efficacious and new inbuilt 6,5-fused bicyclic removable directing group. This protocol is scalable, exhibits high levels of β-site selectivity and tolerates a broad spectrum of functional groups.

中文翻译：

钯催化的8-氨基咪唑并[1,2-a]吡啶（AIP）定向选择性β-C（sp2）–H芳基化

本文首次报道了羧酸衍生物的惰性β-C（sp ²）-H键的钯催化的芳基化反应，首次使用8-氨基咪唑并[1,2- a ]吡啶（AIP）作为有效的新型内嵌化合物6， 5-稠合的双环可移动导向基团。该协议是可扩展的，具有高水平的β-位点选择性，并能耐受各种官能团。

更新日期：2020-12-15

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