Cyclohexan-1,3-dione derivatives are versatile scaffolds for the synthesis of a variety of value-added organic molecules including heterocycles and natural products. Six-membered oxygen heterocycles prepared from cyclohexan-1,3-diones are of much importance as they are intermediate for the synthesis of a number of natural products and several other valuable bioactive molecules which shows anti-viral, anti-bacterial, analgesic, antimalarial, anti-inflammatory, anti-allergic, anti-tumor and anti-cancer activities. These advantages have inspired us to write a detailed survey on the newly developed methods which are very essential in the construction of six-membered oxygen heterocycles. Further, the versatility in the chemistry of cyclohexan-1,3-dione and its derivatives is due to the presence of highly active methylene moiety and its active di-carbonyl groups. Recently, reactions of cyclohexane-1,3-dione and its derivatives with other substrates for instance aldehydes, malononitriles, NMSM, chalcones, isatin etc. have been established for the construction of a variety of six-membered oxygen heterocycles. The studies reported in this review article involved the synthesis of six-membered oxygen-containing heterocycles which includes 4H-chromen-5(6H)-one, 2H-xanthen-1(9H)-one, 2H-xanthen-1,8(5H,9H)-dione, 6H-chromen-2,5-dione derivatives and natural products having six-membered oxygen heterocycles from cyclohexane-1,3-dione and its derivatives as one of the substrate.

环己-1,3-二酮衍生物是合成各种高附加值有机分子（包括杂环和天然产物）的多功能支架。由环己-1,3-二酮制备的六元氧杂环非常重要，因为它们是合成许多天然产物和其他几种具有抗病毒、抗菌、镇痛、抗疟作用的有价值的生物活性分子的中间体、抗炎、抗过敏、抗肿瘤和抗癌活性。这些优势激发了我们对新开发的方法进行详细调查，这些方法对于构建六元氧杂环非常重要。此外，环己-1化学的多功能性，3-二酮及其衍生物是由于存在高活性亚甲基部分及其活性二羰基。最近，已建立环己烷-1,3-二酮及其衍生物与其他底物如醛、丙二腈、NMSM、查耳酮、靛红等的反应，用于构建各种六元氧杂环。这篇综述文章中报道的研究涉及六元含氧杂环的合成，包括 4H-chromen-5(6H)-one、2H-xanthen-1(9H)-one、2H-xanthen-1,8( 5H,9H)-二酮、6H-色烯-2,5-二酮衍生物和具有六元氧杂环的天然产物，以环己烷-1,3-二酮及其衍生物为底物之一。丙二腈、NMSM、查耳酮、靛红等已被建立用于构建各种六元氧杂环。这篇综述文章中报道的研究涉及六元含氧杂环的合成，包括 4H-chromen-5(6H)-one、2H-xanthen-1(9H)-one、2H-xanthen-1,8( 5H,9H)-二酮、6H-色烯-2,5-二酮衍生物和具有六元氧杂环的天然产物，以环己烷-1,3-二酮及其衍生物为底物之一。丙二腈、NMSM、查耳酮、靛红等已被建立用于构建各种六元氧杂环。这篇综述文章中报道的研究涉及六元含氧杂环的合成，包括 4H-chromen-5(6H)-one、2H-xanthen-1(9H)-one、2H-xanthen-1,8( 5H,9H)-二酮、6H-色烯-2,5-二酮衍生物和具有六元氧杂环的天然产物，以环己烷-1,3-二酮及其衍生物为底物之一。