Arene cis-dihydrodiols: useful precursors for the preparation of analogues of the anti-tumour agent, 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC).,Bioorganic & Medicinal Chemistry Letters

当前位置： X-MOL 学术 › Bioorg. Med. Chem. Lett. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Arene cis-dihydrodiols: useful precursors for the preparation of analogues of the anti-tumour agent, 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC).
Bioorganic & Medicinal Chemistry Letters ( IF 2.5 ) Pub Date : 2007 Nov 1 , DOI: 10.1016/j.bmcl.2007.07.070
Claire L Arthurs ₁ , James Raftery , Helen L Whitby , Roger C Whitehead , Natasha S Wind , Ian J Stratford

Affiliation

The synthesis of 6-epi-COTC, a diastereoisomer of Streptomyces metabolite 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC), is described. The anti-cancer activities of the novel analogue, in racemic and enantiomerically pure forms, are presented.

中文翻译：

芳烃顺式二氢二醇：用于制备抗肿瘤剂类似物的有用前体，2-巴豆酰氧基甲基-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC)。

描述了 6-epi-COTC，链霉菌代谢物 2-巴豆酰氧基甲基-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC) 的非对映异构体的合成。介绍了外消旋和对映体纯形式的新型类似物的抗癌活性。

更新日期：2017-01-31

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南