Selenium-Containing Proteins/Peptides from Plants: A Review on the Structures and Functions,Journal of Agricultural and Food Chemistry

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Selenium-Containing Proteins/Peptides from Plants: A Review on the Structures and Functions
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2020-12-14 , DOI: 10.1021/acs.jafc.0c05594
Xing Zhang ₁ , Hui He ₁ , Jiqian Xiang ₂ , Hongqing Yin ₂ , Tao Hou ₁

Affiliation

Selenium is an essential microelement required for biological processes. Traditional selenium supplements (selenite and selenomethionine mainly) remain concerns due to toxicity and bioavailability. In recent decades, biofortification strategies have been applied to produce selenium-enriched edible plants to address the challenges of superior nutritional quality requirements. Plant-derived selenium-containing proteins/peptides offer potential health benefits beyond the basic nutritional requirements of Se. Highly nucleophilic seleno-amino acids, special peptide sequences, and favorable bioavailability contribute to the biological activities of selenium-containing proteins/peptides, such as antioxidant, antihypertensive, anti-inflammatory, and immunomodulatory effects. However, their applications on a commercial scale are insufficient owing to the complexity of purification and identification techniques and the sparse information on bioavailability and metabolism. In this review, selenium status, structural features, bioactivities, structure–activity relationships, and bioavailability, as well as the mechanisms underlying the bioactivities and metabolism of plant-derived selenium-containing proteins/peptides, are summarized and discussed for their nutraceutical use.

中文翻译：

植物中的硒蛋白/肽：结构与功能研究

硒是生物过程中必不可少的微量元素。由于毒性和生物利用度，传统的硒补充剂（主要是亚硒酸盐和硒代蛋氨酸）仍然令人担忧。在最近的几十年中，生物强化策略已被用于生产富硒的食用植物，以应对更高营养质量要求的挑战。除硒的基本营养要求外，植物来源的含硒蛋白质/肽具有潜在的健康益处。高度亲核性的硒氨基酸，特殊的肽序列和良好的生物利用度有助于含硒的蛋白质/肽的生物活性，例如抗氧化剂，抗高血压，抗炎和免疫调节作用。然而，由于纯化和鉴定技术的复杂性以及有关生物利用度和代谢的稀疏信息，它们在商业规模上的应用还不够。在这篇综述中，对硒的状态，结构特征，生物活性，结构-活性关系和生物利用度以及植物衍生的含硒蛋白质/肽的生物活性和代谢的潜在机制进行了总结和讨论，以用于营养保健用途。

更新日期：2020-12-23

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