Vialinin A, a powerful inhibitor (IC50 90 pM) of TNF-alpha production, was synthesized from sesamol in 11 steps with 28% overall yield. The key reactions include a double Suzuki coupling of electron-rich aryl triflate with phenylboronic acid and an oxidative deprotection of bis-MOM ether. In addition, the related synthetic studies also suggest the necessity for structural revision of ganbajunin C, a positional isomer of vialinin A.

中文翻译：

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Vialinin A的第一个全合成，这是一种新型且非常有效的TNF-α抑制剂。

从芝麻素中分11步合成了功能强大的TNF-α抑制剂（IC50 90 pM）Vialinin A，总产率为28％。关键反应包括富电子的三氟甲磺酸芳基酯与苯基硼酸的双Suzuki偶联和bis-MOM醚的氧化脱保护。此外，相关的合成研究还表明，对甘菊碱C（一种小林蛋白A的位置异构体）进行结构修订的必要性。