顺序释放双药物（分级分布）明胶微球/ PMMA骨水泥,Journal of Materials Chemistry B

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顺序释放双药物（分级分布）明胶微球/ PMMA骨水泥
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-11-23 , DOI: 10.1039/d0tb01452d
Lei Chen _{1,

2,

3,

4} , Yufei Tang _{1,

2,

3,

4} , Kang Zhao _{1,

2,

3,

4} , Xiang Zha _{1,

2,

3,

4} , Min Wei _{1,

2,

3,

4} , Quanchang Tan _{4,

5,

6,

7,

8} , Zixiang Wu _{4,

5,

6,

7,

8}

Affiliation

将药物加载到PMMA骨水泥中，以减少新鲜植入的假体中感染的风险或促进成骨细胞的分化和生长。然而，基于患者的临床需求，在骨水泥中加载药物的相同方法不能同时实现有效的抗菌反应和骨质疏松症的长期治疗效果。在本研究中，制备了硫酸庆大霉素（GS）/阿仑膦酸盐（ALN）-双明胶改性的PMMA骨水泥（GAPBC），以提供快速，连续的抗生素释放和长期的抗骨质疏松治疗。具体地，使用单独的方法将明胶微球载有药物，即在明胶微球的制造过程中将ALN载样，然后将GS从溶液吸收到明胶上。结果表明，实现了GS和ALN的顺序释放，其中GS释放在最初的24小时内起主要作用，而在PBS中浸泡3周后，ALN释放起主要作用，这是由明胶微球内的梯度分布和最终改性骨水泥中GS（73.6％）和ALN（68.5％）的药物释放率显着高于PMMA骨水泥。因此，GAPBC代表了未来临床应用的潜在药物载体。改性骨水泥的5％）显着高于PMMA骨水泥。因此，GAPBC代表了未来临床应用的潜在药物载体。改性骨水泥的5％）显着高于PMMA骨水泥。因此，GAPBC代表了未来临床应用的潜在药物载体。

"点击查看英文标题和摘要"

Sequential release of double drug (graded distribution) loaded gelatin microspheres/PMMA bone cement

Drugs are loaded into PMMA bone cement to reduce the risk of infection in freshly implanted prostheses or to promote the differentiation and growth of osteoblasts. However, the same method of loading of drugs in the bone cement cannot simultaneously achieve an effective antibacterial response and long-term treatment outcomes for osteoporosis based on a patient's clinical needs. In the present study, gentamicin sulfate (GS)/alendronate (ALN)-dual-loaded gelatin modified PMMA bone cement (GAPBC) was fabricated to provide rapid and continuous antibiotic release and long-term anti-osteoporotic therapy. Specifically, the gelatin microspheres were loaded with the drugs using separate methodologies, namely, ALN was loaded during fabrication of the gelatin microspheres after which GS was absorbed onto the gelatin from solution. The results demonstrate that sequential release of the GS and ALN was achieved, GS release playing a major role over the first 24 hours and ALN release dominant after 3 weeks of immersion in PBS, resulting from the graded distribution within the gelatin microspheres, and the final drug release ratio of GS (73.6%) and ALN (68.5%) from the modified bone cement was significantly higher than from PMMA bone cement. Therefore, GAPBC represents a potential drug carrier for future clinical applications.

更新日期：2020-12-23

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