NLRP6 炎症小体,Immunology

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NLRP6 炎症小体
Immunology ( IF 4.9 ) Pub Date : 2020-12-12 , DOI: 10.1111/imm.13293
Danping Zheng _{1,

2} , Lara Kern ₁ , Eran Elinav _{1,

3}

Affiliation

NOD 样受体家族 pyrin 结构域包含 6 (NLRP6) 是 NOD 样受体 (NLR) 家族的成员，充当识别微生物相关分子模式的细胞溶质先天免疫传感器。在某些情况下，NLRP6 在激活后会募集适配器细胞凋亡相关斑点样蛋白 (ASC) 和炎性 caspase-1 或 caspase-11 形成炎性体，从而介导促炎性细胞因子 IL-18 的成熟和分泌和 IL-1β。在其他情况下，NLRP6 可以独立于炎症小体的方式发挥其功能。NLRP6 炎症小体的严格调控对于维持组织稳态至关重要，而炎症小体的不当激活可能会导致多种疾病的发展。在肠上皮细胞中，NLRP6 炎症小体被认为在调节肠道微生物组组成、杯状细胞功能以及对胃肠道炎症、感染和肿瘤疾病的相关易感性中发挥作用。此外，NLRP6 可能调节肠外疾病。在这篇综述中，我们总结了目前关于 NLRP6 炎症小体及其激活和调节模式的知识，以及其有助于疾病调节的效应子功能。我们讨论了 NLRP6 研究中的当前挑战以及将其功能用于潜在的人类干预的未来前景。我们总结了目前关于 NLRP6 炎症小体及其激活和调节模式的知识，以及其有助于疾病调节的效应子功能。我们讨论了 NLRP6 研究中的当前挑战以及将其功能用于潜在的人类干预的未来前景。我们总结了目前关于 NLRP6 炎症小体及其激活和调节模式的知识，以及其有助于疾病调节的效应子功能。我们讨论了 NLRP6 研究中的当前挑战以及将其功能用于潜在的人类干预的未来前景。

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The NLRP6 inflammasome

The NOD‐like receptor family pyrin domain containing 6 (NLRP6), a member of the NOD‐like receptor (NLR) family, acts as a cytosolic innate immune sensor that recognizes microbe‐associated molecular patterns. In some circumstances upon activation, NLRP6 recruits the adaptor apoptosis‐associated speck‐like protein (ASC) and the inflammatory caspase‐1 or caspase‐11 to form an inflammasome, which mediates the maturation and secretion of the pro‐inflammatory cytokines IL‐18 and IL‐1β. In other contexts, NLRP6 can exert its function in an inflammasome‐independent manner. Tight regulation of the NLRP6 inflammasome is critical in maintaining tissue homeostasis, while improper inflammasome activation may contribute to the development of multiple diseases. In intestinal epithelial cells, the NLRP6 inflammasome is suggested to play a role in regulating gut microbiome composition, goblet cell function and related susceptibility to gastrointestinal inflammatory, infectious and neoplastic diseases. Additionally, NLRP6 may regulate extra‐intestinal diseases. In this review, we summarize current knowledge on the NLRP6 inflammasome and its activation and regulation patterns, as well as its effector functions contributing to disease modulation. We discuss current challenges in NLRP6 research and future prospects in harnessing its function into potential human interventions.

更新日期：2021-02-16

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