Cell adhesion is one of the basic phenomena occurring in a living organism, affecting many other processes such as proliferation, differentiation, migration, or cell viability. Mast cells (MCs) are important elements involved in defending the host against various pathogens and regulating inflammatory processes. Due to numerous mediators, they are contributing to the modulation of many basic cellular processes in a variety of cells, including the expression and functioning of different adhesive molecules. They also express themselves many adhesive proteins, including ICAM-1, ICAM-3, VCAM-1, integrins, L-selectin, E-cadherin, and N-cadherin. These molecules enable MCs to interact with other cells and components of the extracellular matrix (ECM), creating structures such as adherens junctions and focal adhesion sites, and triggering a signaling cascade. A thorough understanding of these cellular mechanisms can create a better understanding of MC biology and reveal new goals for MC targeted therapy. This review will focus on the current knowledge of adhesion mechanisms with the involvement of MCs. It also provides insight into the influence of MCs or MC-derived mediators on the adhesion molecule expression in different cells.

中文翻译：

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肥大细胞粘附的艺术


细胞粘附是活体中发生的基本现象之一，影响许多其他过程，例如增殖、分化、迁移或细胞活力。肥大细胞（MC）是保护宿主免受各种病原体侵害和调节炎症过程的重要元素。由于存在大量介质，它们有助于调节各种细胞中的许多基本细胞过程，包括不同粘附分子的表达和功能。它们还表达许多粘附蛋白，包括 ICAM-1、ICAM-3、VCAM-1、整合素、L-选择素、E-钙粘蛋白和 N-钙粘蛋白。这些分子使 MC 能够与其他细胞和细胞外基质 (ECM) 成分相互作用，形成粘附连接和粘着斑位点等结构，并触发信号级联。彻底了解这些细胞机制可以更好地理解 MC 生物学，并揭示 MC 靶向治疗的新目标。本综述将重点关注 MC 参与的粘附机制的当前知识。它还提供了关于 MC 或 MC 衍生介质对不同细胞中粘附分子表达的影响的见解。