Equol, a nonsteroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzein, has been synthesized as both enantioenriched forms based on MacMillan’s α-arylation of carbonyl compound mediated by amino acid derived indazolidinones and copper precatalysts. The natural form of (S)-equol and its enantiomer (R)-equol have been synthesized in 8 steps from 2,4-dimethoxybenzaldehyde with good enantiomeric purity (90% ee and 90% ee, respectively).

中文翻译：

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酚醛的对映异构体的简便合成

Equol是一种由异黄酮类植物雌激素黄豆苷元的代谢产生的非甾体雌激素，已被合成为对映体富集形式，这是基于MacMillan的羰基化合物的α-芳基化作用而产生的，该化合物由衍生自吲哚唑烷酮的氨基酸和铜前催化剂介导。（S）-雌马酚及其对映异构体（R）-雌马酚的天然形式已经由具有良好对映体纯度（分别为90％ee和90％ee）的2,4-二甲氧基苯甲醛分8个步骤合成。