当前位置：
X-MOL 学术
›
ACS Appl. Mater. Interfaces
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
In Vivo Bioimaging and Photodynamic Therapy Based on Two-Photon Fluorescent Conjugated Polymers Containing Dibenzothiophene-S,S-dioxide Derivatives
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2020-12-09 , DOI: 10.1021/acsami.0c12955
Liwen Hu 1, 2 , Zikang Chen 3, 4 , Yanshan Liu 4 , Bishan Tian 5 , Ting Guo 1 , Ruiyuan Liu 3, 4 , Chunxiao Wang 5 , Lei Ying 1, 2
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2020-12-09 , DOI: 10.1021/acsami.0c12955
Liwen Hu 1, 2 , Zikang Chen 3, 4 , Yanshan Liu 4 , Bishan Tian 5 , Ting Guo 1 , Ruiyuan Liu 3, 4 , Chunxiao Wang 5 , Lei Ying 1, 2
Affiliation
|
As a critical component for photodynamic therapy toward cancer treatment, photosensitizers require high photoinduced reactive oxygen species generation efficiency, good biocompatibility, and high phototoxicity. Herein, a series of donor–acceptor conjugated polymers containing dibenzothiophene-S,S-dioxide derivatives are designed and synthesized, which can be used as effective photosensitizers. The resulting copolymer PTA5 shows strong green light emission with high photoluminescence quantum yields owing to the intercrossed excited state of local existed and charge transfer states. The PTA5 nanoparticles can be fabricated by encapsulation with a biocompatible polymer matrix. Upon excitation at 800 nm, these nanoparticles present a relatively large two-photon absorption cross section of 3.29 × 106 GM. These nanoparticles also exhibit good photostability in water and thus can be utilized for bioimaging. The tissue-penetrating depths of up to 170 μm for hepatic vessels and 380 μm for blood vessels of mouse ear were achieved using PTA5 nanoparticles. Furthermore, PTA5 nanoparticles show impressive reactive oxygen species generation capability under the irradiation of a white light source. This can be attributed to the effective intersystem crossing between high-level excited state. Upon irradiation with white light (400–700 nm) at 50 mW cm–2 for 5 min every other day, the tumor growth can be effectively suppressed in the presence of PTA5 nanoparticles. These findings demonstrate that PTA5 nanoparticles can be used as a photosensitizer for photodynamic therapy.
中文翻译：
基于含二苯并噻吩-S，S-二氧化物衍生物的双光子荧光共轭聚合物的体内生物成像和光动力疗法
作为光动力疗法治疗癌症的重要组成部分，光敏剂需要高的光诱导活性氧生成效率，良好的生物相容性和高光毒性。此处，一系列供体-受体共轭聚合物的含dibenzothiophene-小号，小号设计并合成了α-二氧化物衍生物，可用作有效的光敏剂。所得共聚物PTA5由于局部存在的激发态和电荷转移态的交叉激发而显示出具有高光致发光量子产率的强绿色发光。PTA5纳米颗粒可以通过与生物相容性聚合物基质包封来制备。在800 nm处激发后，这些纳米颗粒的相对较大的双光子吸收截面为3.29×10 6。总经理 这些纳米粒子在水中也表现出良好的光稳定性，因此可用于生物成像。使用PTA5纳米粒子可实现肝穿刺深度为170μm，小鼠耳穿刺深度为380μm。此外，PTA5纳米颗粒在白光源照射下显示出令人印象深刻的活性氧物种生成能力。这可以归因于高水平激发态之间有效的系统间交叉。每隔一天以50 mW cm –2的白光（400–700 nm）照射5分钟，在PTA5纳米粒子存在下可以有效地抑制肿瘤的生长。这些发现证明PTA5纳米颗粒可以用作光动力疗法的光敏剂。
更新日期：2020-12-23
中文翻译：
基于含二苯并噻吩-S，S-二氧化物衍生物的双光子荧光共轭聚合物的体内生物成像和光动力疗法
作为光动力疗法治疗癌症的重要组成部分，光敏剂需要高的光诱导活性氧生成效率，良好的生物相容性和高光毒性。此处，一系列供体-受体共轭聚合物的含dibenzothiophene-小号，小号设计并合成了α-二氧化物衍生物，可用作有效的光敏剂。所得共聚物PTA5由于局部存在的激发态和电荷转移态的交叉激发而显示出具有高光致发光量子产率的强绿色发光。PTA5纳米颗粒可以通过与生物相容性聚合物基质包封来制备。在800 nm处激发后，这些纳米颗粒的相对较大的双光子吸收截面为3.29×10 6。总经理 这些纳米粒子在水中也表现出良好的光稳定性，因此可用于生物成像。使用PTA5纳米粒子可实现肝穿刺深度为170μm，小鼠耳穿刺深度为380μm。此外，PTA5纳米颗粒在白光源照射下显示出令人印象深刻的活性氧物种生成能力。这可以归因于高水平激发态之间有效的系统间交叉。每隔一天以50 mW cm –2的白光（400–700 nm）照射5分钟，在PTA5纳米粒子存在下可以有效地抑制肿瘤的生长。这些发现证明PTA5纳米颗粒可以用作光动力疗法的光敏剂。
京公网安备 11010802027423号