New Promises from an Old Friend: Iodine-Rich Compounds as Prospective Energetic Biocidal Agents,Accounts of Chemical Research

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New Promises from an Old Friend: Iodine-Rich Compounds as Prospective Energetic Biocidal Agents
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2020-12-10 , DOI: 10.1021/acs.accounts.0c00623
Jinjie Chang ₁ , Gang Zhao ₂ , Xinyuan Zhao ₃ , Chunlin He _{1,

2,

3} , Siping Pang _{1,

3} , Jean'ne M Shreeve ₂

Affiliation

For a very long time, frequent occurrences of biocrises have wreaked havoc on human beings, animals, and the environment. As a result, it is necessary to develop biocidal agents to destroy or neutralize active agents by releasing large amounts of strong biocides which are obtained upon detonation. Iodine is an efficient biocidal agent for bacteria, fungi, yeasts, viruses, spores, and protozoan parasites, and it is the sole element in the periodic table that can destroy microbes without contaminating the environment. Based on chemical biology, the mechanism of iodine as a bactericide may arise from oxidation and iodination reactions of cellular proteins and nucleic acids. However, because of the high vapor pressure causing elemental iodine to sublime readily at room temperature, it is inconvenient to use this material in its normal solid state directly as a biocidal agent under ambient conditions. Iodine-rich compounds where iodine is firmly bonded in molecules as a C–I or I–O moiety have been observed to be among the most promising energetic biocidal compounds. Gaseous products comprised of large amounts of iodine or iodine-containing components as strong biocides are released in the decomposition or explosion of iodine-rich compounds. Because of the detonation pressure, the iodine species are distributed over a large area greatly improving the efficacy of the system and requiring considerably less effort compared to traditional biocidal methods. The commercially available tetraiodomethane and tetraiodoethene, which possess superb iodine content also have the disadvantages of volatility, light sensitivity, and chemically reactivity, and therefore, are not suitable for use directly as biocidal agents. It is absolutely critical to synthesize new iodine-rich compounds with good thermal and chemical stabilities.

中文翻译：

一位老朋友的新承诺：富含碘的化合物作为潜在的高能杀生物剂

长期以来，频繁发生的生物危机给人类，动物和环境造成了严重破坏。结果，有必要开发杀生物剂以通过释放爆炸时获得的大量强杀生物剂来破坏或中和活性剂。碘是细菌，真菌，酵母，病毒，孢子和原生动物寄生虫的有效杀生物剂，它是元素周期表中可以破坏微生物而不污染环境的唯一元素。基于化学生物学，碘作为杀菌剂的机理可能源于细胞蛋白质和核酸的氧化和碘化反应。但是，由于高蒸气压会导致元素碘在室温下容易升华，在环境条件下直接以其正常固态使用这种材料作为杀菌剂是不方便的。碘在分子中作为C–I或I–O部分牢固结合的富含碘的化合物被认为是最有前途的高能杀生物化合物。含有大量碘或含碘组分作为强杀菌剂的气体产物会在富含碘的化合物的分解或爆炸中释放出来。由于爆炸压力，碘物质分布在大面积上，大大提高了系统的效率，与传统的杀菌方法相比，所需的工作量大大减少。具有高碘含量的市售四碘甲烷和四碘乙烯也具有挥发性，光敏性，和化学反应性，因此不适合直接用作杀菌剂。合成具有良好的热稳定性和化学稳定性的新的富含碘的化合物至关重要。

更新日期：2021-01-19

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