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Two new baccharane glycosides from seeds of Impatientis balsamina L. with in vitro growth inhibitory activity in human cancer A375 cells
Chemical Research in Chinese Universities ( IF 1.063 ) Pub Date : 2017-09-12 , DOI: 10.1007/s40242-017-7061-6 Qian Wu , Yongri Jin , Hua Yao , Ying Liu , Peng Li , Xuwen Li
Chemical Research in Chinese Universities ( IF 1.063 ) Pub Date : 2017-09-12 , DOI: 10.1007/s40242-017-7061-6 Qian Wu , Yongri Jin , Hua Yao , Ying Liu , Peng Li , Xuwen Li
Two new baccharane-type glycosides (
1
and
2
), together with seven known baccharane-type glycosides (
3
―
9
) hosenkoside A, hosenkoside B, hosenkoside C, hosenkoside F, hosenkoside M, hosenkoside K and hosenkoside G were isolated from the dried seeds of
Impatientis balsamina
L. The new baccharane-type glycosides were identified as honsenkol A-3-
O
-
β
-
D
-glucopyranosyl-26-
O
-
β
-
D
-glucopyranosyl-28-
O
-
β
-
D
-glucopyranosyl-
O
-
β
-
D
-glucopyranosyl(
1
) and (3
S
,4
R
,17
R
,20
S
)-17-hydroxy-3-
O
-
β
-
D
-xylopyranose(12)-
β
-
D
-glucopyranosyl-26-
O
-
β
-
D
-glucopyranosyl-28-
O
-
β
-
D
-glucopyranosyl-21,24-epoxybaccharane(
2
), respectively, by spectroscopic methods, including NMR(1D and 2D), IR and HR-ESI-MS. Compounds
1
and
2
were evaluated for
in vitro
inhibitory activity against the cell lines. Compound
2
with a new baccharane skeleton had anti-hepatic fibrosis activity against A375 cells in bioassay results, which means the new compounds have potential value in antitumor applications.
中文翻译:
香茅( Impatientis balsamina L.)种子中的两种新的baccharane苷 具有 对人癌细胞A375细胞的 体外 生长抑制活性
从干燥的干粉中分离出两种新的葡聚糖型糖苷( 1 和 2 ),以及七种已知的葡聚糖型糖苷( 3 至 9 )。的种子 Impatientis凤仙花 L.新baccharane型糖苷被鉴定为honsenkol A-3- ø - β - d 吡喃葡萄糖基- 26- ø - β - d 吡喃葡萄糖基- 28- ø - β - d -glucopyranosyl- ø - β - d 吡喃葡萄糖基( 1 )和(3 小号 ,4 - [R 17 - [R ,20 小号 )-17-羟基-3- ø - β - d -xylopyranose(12) - β - d 吡喃葡萄糖基- 26- O - β - D- 吡喃 葡萄糖基-28- O - β - D- 吡喃葡萄糖基-21,24-环氧丁烷( 2 ),分别通过光谱方法,包括NMR(1D和2D),IR和HR-ESI-MS。评价 化合物 1 和 2 对细胞系的 体外 抑制活性。在生物测定结果中,具有新葡聚糖骨架的化合物 2 对A375细胞具有抗肝纤维化活性,这意味着该新化合物在抗肿瘤应用中具有潜在价值。
更新日期:2017-09-12
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
香茅( Impatientis balsamina L.)种子中的两种新的baccharane苷 具有 对人癌细胞A375细胞的 体外 生长抑制活性
从干燥的干粉中分离出两种新的葡聚糖型糖苷( 1 和 2 ),以及七种已知的葡聚糖型糖苷( 3 至 9 )。的种子 Impatientis凤仙花 L.新baccharane型糖苷被鉴定为honsenkol A-3- ø - β - d 吡喃葡萄糖基- 26- ø - β - d 吡喃葡萄糖基- 28- ø - β - d -glucopyranosyl- ø - β - d 吡喃葡萄糖基( 1 )和(3 小号 ,4 - [R 17 - [R ,20 小号 )-17-羟基-3- ø - β - d -xylopyranose(12) - β - d 吡喃葡萄糖基- 26- O - β - D- 吡喃 葡萄糖基-28- O - β - D- 吡喃葡萄糖基-21,24-环氧丁烷( 2 ),分别通过光谱方法,包括NMR(1D和2D),IR和HR-ESI-MS。评价 化合物 1 和 2 对细胞系的 体外 抑制活性。在生物测定结果中,具有新葡聚糖骨架的化合物 2 对A375细胞具有抗肝纤维化活性,这意味着该新化合物在抗肿瘤应用中具有潜在价值。