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Two new baccharane glycosides from seeds of Impatientis balsamina L. with in vitro growth inhibitory activity in human cancer A375 cells
Chemical Research in Chinese Universities ( IF 1.063 ) Pub Date : 2017-09-12 , DOI: 10.1007/s40242-017-7061-6
Qian Wu , Yongri Jin , Hua Yao , Ying Liu , Peng Li , Xuwen Li

Two new baccharane-type glycosides ( 1 and 2 ), together with seven known baccharane-type glycosides ( 3 9 ) hosenkoside A, hosenkoside B, hosenkoside C, hosenkoside F, hosenkoside M, hosenkoside K and hosenkoside G were isolated from the dried seeds of Impatientis balsamina L. The new baccharane-type glycosides were identified as honsenkol A-3- O - β - D -glucopyranosyl-26- O - β - D -glucopyranosyl-28- O - β - D -glucopyranosyl- O - β - D -glucopyranosyl( 1 ) and (3 S ,4 R ,17 R ,20 S )-17-hydroxy-3- O - β - D -xylopyranose(12)- β - D -glucopyranosyl-26- O - β - D -glucopyranosyl-28- O - β - D -glucopyranosyl-21,24-epoxybaccharane( 2 ), respectively, by spectroscopic methods, including NMR(1D and 2D), IR and HR-ESI-MS. Compounds 1 and 2 were evaluated for in vitro inhibitory activity against the cell lines. Compound 2 with a new baccharane skeleton had anti-hepatic fibrosis activity against A375 cells in bioassay results, which means the new compounds have potential value in antitumor applications.

中文翻译:

香茅( Impatientis balsamina L.)种子中的两种新的baccharane苷 具有 对人癌细胞A375细胞的 体外 生长抑制活性

从干燥的干粉中分离出两种新的葡聚糖型糖苷( 1 2 ),以及七种已知的葡聚糖型糖苷( 3 9 )。的种子 Impatientis凤仙花 L.新baccharane型糖苷被鉴定为honsenkol A-3- ø - β - d 吡喃葡萄糖基- 26- ø - β - d 吡喃葡萄糖基- 28- ø - β - d -glucopyranosyl- ø - β - d 吡喃葡萄糖基( 1 )和(3 小号 ,4 - [R 17 - [R ,20 小号 )-17-羟基-3- ø - β - d -xylopyranose(12) - β - d 吡喃葡萄糖基- 26- O - β - D- 吡喃 葡萄糖基-28- O - β - D- 吡喃葡萄糖基-21,24-环氧丁烷( 2 ),分别通过光谱方法,包括NMR(1D和2D),IR和HR-ESI-MS。评价 化合物 1 2 对细胞系的 体外 抑制活性。在生物测定结果中,具有新葡聚糖骨架的化合物 2 对A375细胞具有抗肝纤维化活性,这意味着该新化合物在抗肿瘤应用中具有潜在价值。
更新日期:2017-09-12
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