An optimized process for the preparation of 6-hydroxybenzofuran is described. This process consists of three steps: the reaction of 2-hydroxy-4-methoxybenzaldehyde with chloroacetic acid, the formation of the 6-methoxybenzofuran in acetic anhydride, and the demethylation with sodium 1-dodecanethiolate to afford the desired product. The entire process is safe, cost effective, environmentally benign, and scalable. A production scale of over 2.6 kg product was achieved in good overall yield.

中文翻译：

---

改进的按比例放大合成6-羟基苯并呋喃

描述了制备6-羟基苯并呋喃的优化方法。该方法包括三个步骤：2-羟基-4-甲氧基苯甲醛与氯乙酸的反应；在乙酸酐中形成6-甲氧基苯并呋喃；以及用1-十二烷硫醇钠脱甲基，得到所需的产物。整个过程是安全的，具有成本效益的，环境友好的和可扩展的。总产量达到了2.6公斤以上的产品规模。