Transdermal drug delivery is an attractive route for dermatological disease therapy because it can directly target the lesion site on the skin, reduce adverse reactions associated with systemic administration, and improve patient compliance. However, the stratum corneum, as the main skin barrier, severely limits transdermal drug penetration, with compromised bioavailability. Microneedles (MNs), which are leveraged to markedly improve the penetration of therapeutic agents by piercing the stratum corneum and creating hundreds of reversible microchannels in a minimally invasive manner, have been envisioned as a milestone for effective transdermal drug delivery, especially for superficial disease therapy. Here, the emergence of versatile MNs for the transdermal delivery of various drugs is reviewed, particularly focusing on the application of MNs for the treatment of diverse skin diseases, including superficial tumors, scars, psoriasis, herpes, acne, and alopecia. Additionally, the promises and challenges of the widespread translation of MN-mediated transdermal drug delivery in the dermatology field are summarized.

透皮药物递送是皮肤病学治疗的一种有吸引力的途径，因为它可以直接靶向皮肤上的病变部位，减少与全身性给药相关的不良反应，并改善患者的依从性。但是，角质层作为主要的皮肤屏障，严重限制了透皮药物的渗透，降低了生物利用度。微针（MNs）被认为是通过刺穿角质层并以微创方式创建数百个可逆微通道的方法，可显着提高治疗剂的渗透性，已被视为实现有效透皮药物输送（尤其是浅表疾病治疗）的里程碑。在这里，我们综述了用于多种药物经皮递送的多功能MN的出现，特别是将MNs用于治疗多种皮肤疾病，包括浅表肿瘤，疤痕，牛皮癣，疱疹，痤疮和脱发。另外，总结了在皮肤病学领域中MN介导的透皮药物递送的广泛翻译的前景和挑战。