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Adhesive, Self-Healing, and Antibacterial Chitosan Hydrogels with Tunable Two-Layer Structures
ACS Sustainable Chemistry & Engineering ( IF 7.1 ) Pub Date : 2020-12-04 , DOI: 10.1021/acssuschemeng.0c05730 Yinggui Wang 1, 2 , Celine R. Garcia 2 , Zhenya Ding 2 , Rebecca Gabrilska 3 , Kendra P. Rumbaugh 3 , Jiangyu Wu 1 , Qingye Liu 2, 4 , Wei Li 2
ACS Sustainable Chemistry & Engineering ( IF 7.1 ) Pub Date : 2020-12-04 , DOI: 10.1021/acssuschemeng.0c05730 Yinggui Wang 1, 2 , Celine R. Garcia 2 , Zhenya Ding 2 , Rebecca Gabrilska 3 , Kendra P. Rumbaugh 3 , Jiangyu Wu 1 , Qingye Liu 2, 4 , Wei Li 2
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Hydrogels with multifunctional properties such as biocompatibility, adhesion, and self-healing and inherent antibacterial properties are of great significance in biomedical applications, especially for wound dressings and drug release. However, it remains a significant challenge to combine all of these properties in a one-component hydrogel system. Furthermore, most injectable hydrogels are mechanically weak and not self-healing, which limits their applications as wound dressings. Herein, we designed a hydrogel with a tunable two-layer structure that endows the hydrogel with adhesion, self-healing, and antibacterial properties in different layers. First, chitosan (CHI) was oxidized to aldehyde-chitosan (ACHI). The Schiff base reaction was then used to fabricate the CHI/ACHI hydrogel resulting in the first layer. For the second layer, a physical cross-linking process using phytic acid (PA) as a sequential cross-linker was achieved, resulting in a CHI/ACHI/PA hydrogel. The CHI/ACHI hydrogel exhibited good injectable, adhesion, and self-healing properties. After cross-linking with PA, the CHI/ACHI/PA hydrogel showed enhanced mechanical properties, which enabled it to act as a protective layer. Additionally, the antibacterial test and cytotoxicity tests performed on this two-layer structured CHI/ACHI hydrogel exhibited excellent inherent antibacterial activity and good biocompatibility. The biocompatible injectable hydrogel was endowed with more possibilities relying on its self-healing and antibacterial abilities. These properties endorse the CHI/ACHI two-layer hydrogel as an excellent candidate for biological applications, especially wound dressings.
中文翻译：
具有可调两层结构的胶粘剂，自修复性和抗菌壳聚糖水凝胶
具有多功能特性（如生物相容性，粘附性，自愈性和固有的抗菌特性）的水凝胶在生物医学应用中，特别是在伤口敷料和药物释放中，具有重要意义。然而，将所有这些性质结合在单组分水凝胶体系中仍然是一个巨大的挑战。此外，大多数可注射水凝胶在机械上较弱并且不能自我修复，这限制了其作为伤口敷料的应用。在本文中，我们设计了一种具有可调两层结构的水凝胶，使水凝胶在不同的层中具有附着力，自愈性和抗菌性能。首先，将壳聚糖（CHI）氧化为醛-壳聚糖（ACHI）。然后使用席夫碱反应制备第一层的CHI / ACHI水凝胶。对于第二层 实现了使用植酸（PA）作为顺序交联剂的物理交联过程，从而获得了CHI / ACHI / PA水凝胶。CHI / ACHI水凝胶具有良好的可注射性，粘附性和自愈性。与PA交联后，CHI / ACHI / PA水凝胶显示出增强的机械性能，使其能够充当保护层。另外，对该两层结构的CHI / ACHI水凝胶进行的抗菌测试和细胞毒性测试显示出优异的固有抗菌活性和良好的生物相容性。生物相容性可注射水凝胶凭借其自愈和抗菌能力被赋予了更多的可能性。这些特性证明CHI / ACHI两层水凝胶非常适合用于生物学应用，尤其是伤口敷料。
更新日期：2020-12-14
中文翻译：
具有可调两层结构的胶粘剂，自修复性和抗菌壳聚糖水凝胶
具有多功能特性（如生物相容性，粘附性，自愈性和固有的抗菌特性）的水凝胶在生物医学应用中，特别是在伤口敷料和药物释放中，具有重要意义。然而，将所有这些性质结合在单组分水凝胶体系中仍然是一个巨大的挑战。此外，大多数可注射水凝胶在机械上较弱并且不能自我修复，这限制了其作为伤口敷料的应用。在本文中，我们设计了一种具有可调两层结构的水凝胶，使水凝胶在不同的层中具有附着力，自愈性和抗菌性能。首先，将壳聚糖（CHI）氧化为醛-壳聚糖（ACHI）。然后使用席夫碱反应制备第一层的CHI / ACHI水凝胶。对于第二层 实现了使用植酸（PA）作为顺序交联剂的物理交联过程，从而获得了CHI / ACHI / PA水凝胶。CHI / ACHI水凝胶具有良好的可注射性，粘附性和自愈性。与PA交联后，CHI / ACHI / PA水凝胶显示出增强的机械性能，使其能够充当保护层。另外，对该两层结构的CHI / ACHI水凝胶进行的抗菌测试和细胞毒性测试显示出优异的固有抗菌活性和良好的生物相容性。生物相容性可注射水凝胶凭借其自愈和抗菌能力被赋予了更多的可能性。这些特性证明CHI / ACHI两层水凝胶非常适合用于生物学应用，尤其是伤口敷料。
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