Owing to the large inter-subject variability, early post-stroke prognosis is challenging, and objective biomarkers that can provide further prognostic information are still needed. The relation between quantitative EEG parameters in pre-thrombolysis hyper-acute phase and outcomes has still to be investigated. Hence, possible correlations between early EEG biomarkers, measured on bedside wireless EEG, and short-term/long-term functional and morphological outcomes were investigated in thrombolysis-treated strokes. EEG with a wireless device was performed in 20 patients with hyper-acute (< 4.5 h from onset) anterior ischemic stroke before reperfusion treatment. The correlations between outcome parameters (i.e., 7-day/12-month National Institutes of Health Stroke Scale NIHSS, 12-month modified Rankin Scale mRS, final infarct volume) and the pre-treatment EEG parameters were studied. Relative delta power and alpha power, delta/alpha (DAR), and (delta+theta)/(alpha+beta) (DTABR) ratios significantly correlated with NIHSS 7-day (rho = 0.80, − 0.81, 0.76, 0.75, respectively) and NIHSS 12-month (0.73, − 0.78, 0.74, 0.73, respectively), as well as with final infarct volume (0.75, − 0.70, 0.78, 0.62, respectively). A good outcome in terms of mRS ≤ 2 at 12 months was associated with DAR parameter (p = 0.008). The neurophysiological biomarkers obtained by non-invasive and portable technique as wireless EEG in the early pre-treatment phase may contribute as objective parameters to the short/long-term outcome prediction pivotal to better establish the treatment strategies.

Graphical abstract

由于受试者之间存在较大的变异性，中风后的早期预后具有挑战性，仍然需要能够提供进一步预后信息的客观生物标志物。溶栓前超急性期定量 EEG 参数与结果之间的关系仍有待研究。因此，在溶栓治疗的中风中研究了在床边无线脑电图上测量的早期脑电图生物标志物与短期/长期功能和形态学结果之间可能的相关性。在再灌注治疗前，对 20 名超急性（距发病 < 4.5 小时）前壁缺血性卒中患者使用无线设备进行 EEG。结果参数（即 7 天/12 个月美国国立卫生研究院卒中量表 NIHSS、12 个月改良 Rankin 量表 mRS、最终梗塞体积）和治疗前脑电图参数进行了研究。相对 delta power 和 alpha power、delta/alpha (DAR) 和 (delta+theta)/(alpha+beta) (DTABR) 比值与 NIHSS 7 天显着相关（rho = 0.80、- 0.81、0.76、0.75，分别) 和 NIHSS 12 个月（分别为 0.73、- 0.78、0.74、0.73），以及最终梗死​​体积（分别为 0.75、- 0.70、0.78、0.62）。12 个月时 mRS ≤ 2 的良好结果与 DAR 参数相关（p  = 0.008）。在早期预处理阶段通过非侵入性和便携式技术作为无线 EEG 获得的神经生理学生物标志物可以作为客观参数对短期/长期结果预测至关重要，从而更好地制定治疗策略。

图形概要