Four novel rearranged cytochalasans (1–4) were isolated from an endophytic fungus Chaetomium globosum P2-2-2. Pchaeglobolactone A (1) possessed an unprecedented 13-aza-21-oxa-tetracyclo-[10.6.1.2^17,19.0^15,19]henicosane core. Spiropchaeglobosin A (2) was the first example of cytochalasans featuring a novel spiro[5.10]hexadecane unit. Pchaeglobosals A (3) and B (4) featured a unique 5/5/13 fused tricyclic ring system. Compounds 1–4 were tested for their antiproliferative, apoptosis, cell cycle arrest, and TRAIL-resistance-overcoming activities on cancer cell lines.

中文翻译：

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Pchaeglobolactone A、Spiropchaeglobosin A 和 Pchaeglobosals A 和 B：来自 Chaetomium globosum P2-2-2 的四种重排细胞松弛素

四种新型重排cytochalasans（1 - 4）购自的内生真菌分离球毛壳霉P2-2-2。Pchaeglobolactone A ( 1 ) 拥有前所未有的 13-aza-21-oxa-tetracyclo-[10.6.1.2 ^17,19 .0 ^15,19 ]henicosane 核心。Spiropchaeglobosin A ( 2 ) 是第一个具有新型螺[5.10]十六烷单元的细胞松弛素实例。Pchaeglobosals A ( 3 ) 和 B ( 4 ) 具有独特的 5/5/13 稠合三环系统。化合物1 – 4 测试了它们对癌细胞系的抗增殖、细胞凋亡、细胞周期停滞和克服 TRAIL 抗性的活性。