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SARS‐CoV‐2: Bioinspired DNase‐I‐Coated Melanin‐Like Nanospheres for Modulation of Infection‐Associated NETosis Dysregulation (Adv. Sci. 23/2020)
Advanced Science ( IF 14.3 ) Pub Date : 2020-12-02 , DOI: 10.1002/advs.202070132
Hee Ho Park , Wooram Park , Yun Young Lee , Hyelim Kim , Hee Seung Seo , Dong Wook Choi , Ho‐Keun Kwon , Dong Hee Na , Tae‐Hyung Kim , Young Bin Choy , June Hong Ahn , Wonhwa Lee , Chun Gwon Park

In article number 2001940, June Hong Ahn, Wonhwa Lee, Chun Gwon Park, and co‐workers demonstrate that NETosis factor can be a potential therapeutic target for the treatment of SARS‐CoV‐2‐induced sepsis. DNase‐I coated melanin‐like nanospheres (DNase‐I pMNSs) show excellent stability, modulation of sepsis‐associated NETosis dysregulation and prevention of further disease progression.
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中文翻译:

SARS‐CoV‐2:受生物启发的DNase‐I涂层的黑色素样纳米球,可调节感染相关的NETosis失调(Adv。Sci。23/2020)

June Hong Ahn,Wonhwa Lee,Chun Gwon Park及其同事在编号2001940中证明,NETosis因子可以作为治疗SARS-CoV-2引起的败血症的潜在治疗靶标。DNase-I包被的黑色素样纳米球(DNase-I pMNSs)具有出色的稳定性,与败血症相关的NETosis失调的调节作用以及防止疾病进一步发展的能力。
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更新日期:2020-12-03
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