Synthesis of Dihydroquinolines as Scaffolds for Fluorescence Sensing of Hydroxyl Radical,Organic Letters

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Synthesis of Dihydroquinolines as Scaffolds for Fluorescence Sensing of Hydroxyl Radical
Organic Letters ( IF 4.9 ) Pub Date : 2020-12-02 , DOI: 10.1021/acs.orglett.0c03852
Yalan Wu ₁ , Wenyi Huang ₁ , Danfeng Peng ₁ , Xin-an Huang ₁ , Jiangyong Gu ₂ , Shengjun Wu ₁ , Tao Deng ₁ , Fang Liu ₁

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A mild synthetic method to prepare dihydroquinolines has been presented. These dihydroquinolines, for the first time, showed great potential for fluorescence detection of the important biorelevant hydroxyl radicals (^•OH). Sensitive and selective ^•OH detection and intracellular organelle-targeted fluorescence imaging of ^•OH have been demonstrated by using one of the synthetic dihydroquinolines. Moreover, dihydroquinoline has also exhibited promising potential to construct advanced fluorescence probes for ^•OH with tunable photophysical properties.

中文翻译：

合成二氢喹啉作为支架用于羟基自由基的荧光传感

已经提出了制备二氢喹啉的温和的合成方法。这些二氢喹啉首次显示出重要的生物相关羟基自由基（^• OH）荧光检测的巨大潜力。灵敏的和选择性^• OH检测和胞内细胞器靶向荧光成像^• OH已经通过使用合成的二氢喹啉中的一个证明。此外，二氢喹啉还具有构建具有可调光物理特性的^• OH高级荧光探针的潜力。

更新日期：2021-01-01

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