Improving Chronic Diabetic Wound Healing through an Injectable and Self-Healing Hydrogel with Platelet-Rich Plasma Release,ACS Applied Materials & Interfaces

当前位置： X-MOL 学术 › ACS Appl. Mater. Interfaces › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Improving Chronic Diabetic Wound Healing through an Injectable and Self-Healing Hydrogel with Platelet-Rich Plasma Release
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2020-12-01 , DOI: 10.1021/acsami.0c17142
Zhiyong Qian ₁ , Haiping Wang ₂ , Yating Bai ₁ , Yuqing Wang ₁ , Lei Tao ₃ , Yen Wei ₃ , Yubo Fan ₁ , Ximin Guo ₄ , Haifeng Liu ₁

Affiliation

Diabetic skin ulcer is one of the severe complications of diabetes mellitus, which has a high incidence and may cause death or disability. Platelet-rich plasma (PRP) is widely used in the treatment of diabetic wounds due to the effect of growth factors (GFs) derived from it. However, the relatively short half-life of GFs limits their applications in clinics. In addition, the presence of a large amount of proteases in the diabetic wound microenvironment results in the degradation of GFs, which further impedes angiogenesis and diabetic wound healing. In our study, we fabricated a self-healing and injectable hydrogel with a composite of chitosan, silk fibroin, and PRP (CBPGCTS–SF@PRP) for promoting diabetic wound healing. CBPGCTS–SF@PRP could protect PRP from enzymatic hydrolysis, release PRP sustainably, and enhance the chemotaxis of mesenchymal stem cells. The results showed that it could promote the proliferation of repair cells in vitro. Moreover, it could enhance wound healing by expediting collagen deposition, angiogenesis, and nerve repair in a type 2 diabetic rat model and a rat skin defect model. We hope that this study will offer a new treatment for diabetic nonhealing wounds in clinics.

中文翻译：

通过富含血小板的血浆释放的可注射和自愈水凝胶改善慢性糖尿病伤口的愈合

糖尿病性皮肤溃疡是糖尿病的严重并发症之一，其发病率高并且可能导致死亡或致残。富含血小板的血浆（PRP）由于其衍生的生长因子（GFs）的作用而广泛用于治疗糖尿病伤口。但是，GFs相对较短的半衰期限制了其在临床中的应用。另外，在糖尿病伤口微环境中大量蛋白酶的存在导致GFs的降解，这进一步阻碍了血管生成和糖尿病伤口愈合。在我们的研究中，我们制造了一种具有壳聚糖，丝素蛋白和PRP（CBPGCTS-SF @ PRP）的复合物的自愈和可注射水凝胶，以促进糖尿病伤口的愈合。CBPGCTS–SF @ PRP可以保护PRP免受酶水解，持续释放PRP，并增强间充质干细胞的趋化性。结果表明它可以促进修复细胞的增殖体外。此外，它可以通过加速2型糖尿病大鼠模型和大鼠皮肤缺损模型中的胶原蛋白沉积，血管生成和神经修复来增强伤口愈合。我们希望这项研究将为诊所的糖尿病不愈合伤口提供新的治疗方法。

更新日期：2020-12-01

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南