Isochromans are well recognized heterocyclic compounds in drug discovery which produce diverse therapeutically related applications in pharmacological practices. Medicinal chemistry investigators have synthesized drug-like isochroman candidates with multiple medicinal features including central nervous system (CNS), antioxidant, antimicrobial, antihypertensive, antitumor and anti-inflammatory agents. Simultaneously, SAR (Structure-Activity Relationship) analysis has drawn attentions among medicinal chemists, along with a great deal of derivatives have been derived for potential targets. In this article, we thoroughly summarize the biological activities and part of typical SAR for isochroman derivatives reported on existing literatures and patents, wishing to provide an overall retrospect and prospect on the isochroman analogues.

异色满是药物开发中公认的杂环化合物，可在药理实践中产生多种与治疗相关的应用。药物化学研究人员合成了具有多种医学特征的药物样异色满候选物，包括中枢神经系统（CNS），抗氧化剂，抗微生物剂，降压药，抗肿瘤药和抗炎药。同时，SAR（结构-活动关系）分析引起了药物化学家的关注，并且已经衍生出许多潜在目标的衍生物。在本文中，我们彻底总结了现有文献和专利中报道的异色满衍生物的生物学活性和典型SAR的一部分，希望对异色满类似物提供整体的回顾和展望。