The synthesis of variously substituted indolo[2,3-c]quinolin-6(7H)-ones was developed via Pd-catalyzed intramolecular C–H arylation. This method highlights a strategy for preparing indoloquinoline precursors bearing versatile functional groups and provides a new approach for the synthesis of antimalarial isoneocryptolepine analogues. The plausible ring closure mechanism was examined with quantum chemical calculations, where a trigonal bipyramidal concerted metalation–deprotonation transition state is presumable.

中文翻译：

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吲哚并[2，3 - c ]喹啉-6（7 H）-酮的合成及抗疟原虫烯隐油菜碱。Pd催化的分子内C–H芳基化的计算研究

通过Pd催化的分子内C–H芳基化反应，开发了各种取代的吲哚[2,3 - c ]喹啉-6（7 H）-ones的合成。该方法突出了制备带有多功能官能团的吲哚喹啉前体的策略，并为合成抗疟异异烯油菜碱类似物提供了新方法。通过量子化学计算研究了可能的闭环机理，推测是三角双锥体协同的金属化-去质子化过渡态。