Tailored Mesoporous Inorganic Biomaterials: Assembly, Functionalization, and Drug Delivery Engineering,Advanced Materials

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Tailored Mesoporous Inorganic Biomaterials: Assembly, Functionalization, and Drug Delivery Engineering
Advanced Materials ( IF 27.4 ) Pub Date : 2020-11-30 , DOI: 10.1002/adma.202005215
Yidong Zou ₁ , Biaotong Huang ₁ , Liehu Cao _{2,

3} , Yonghui Deng _{4,

5} , Jiacan Su _{1,

2}

Affiliation

Infectious or immune diseases have caused serious threat to human health due to their complexity and specificity, and emerging drug delivery systems (DDSs) have evolved into the most promising therapeutic strategy for drug‐targeted therapy. Various mesoporous biomaterials are exploited and applied as efficient nanocarriers to loading drugs by virtue of their large surface area, high porosity, and prominent biocompatibility. Nanosized mesoporous nanocarriers show great potential in biomedical research, and it has become the research hotspot in the interdisciplinary field. Herein, recent progress and assembly mechanisms on mesoporous inorganic biomaterials (e.g., silica, carbon, metal oxide) are summarized systematically, and typical functionalization methods (i.e., hybridization, polymerization, and doping) for nanocarriers are also discussed in depth. Particularly, structure–activity relationship and the effect of physicochemical parameters of mesoporous biomaterials, including morphologies (e.g., hollow, core–shell), pore textures (e.g., pore size, pore volume), and surface features (e.g., roughness and hydrophilic/hydrophobic) in DDS application are overviewed and elucidated in detail. As one of the important development directions, advanced stimuli‐responsive DDSs (e.g., pH, temperature, redox, ultrasound, light, magnetic field) are highlighted. Finally, the prospect of mesoporous biomaterials in disease therapeutics is stated, and it will open a new spring for the development of mesoporous nanocarriers.

中文翻译：

定制介孔无机生物材料：组装、功能化和药物输送工程

传染性或免疫性疾病因其复杂性和特异性而对人类健康造成严重威胁，新兴的药物递送系统（DDS）已发展成为最有前途的药物靶向治疗策略。各种介孔生物材料因其大表面积、高孔隙率和突出的生物相容性而被开发和应用作为有效的纳米载体来负载药物。纳米介孔纳米载体在生物医学研究中展现出巨大潜力，已成为跨学科领域的研究热点。本文系统地总结了介孔无机生物材料（例如二氧化硅、碳、金属氧化物）的最新进展和组装机制，并深入讨论了纳米载体的典型功能化方法（即杂化、聚合和掺杂）。特别是介孔生物材料的结构-活性关系和物理化学参数的影响，包括形态（例如，空心、核-壳）、孔结构（例如，孔径、孔体积）和表面特征（例如，粗糙度和亲水性/疏水性）在DDS应用中进行了详细的概述和阐述。作为重要的发展方向之一，先进的刺激响应DDS（例如pH、温度、氧化还原、超声、光、磁场）受到关注。最后展望了介孔生物材料在疾病治疗方面的前景，将为介孔纳米载体的发展开启新的春天。

更新日期：2021-01-12

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