Tetrahedral DNA Nanoconjugates for Simultaneous Measurement of Telomerase Activity and miRNA,ChemBioChem

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Tetrahedral DNA Nanoconjugates for Simultaneous Measurement of Telomerase Activity and miRNA
ChemBioChem ( IF 2.6 ) Pub Date : 2020-11-26 , DOI: 10.1002/cbic.202000784
Chenyu Jiang _{1,

2} , Fanyu Meng ₃ , Dongsheng Mao ₄ , Yuguo Tang ₁ , Peng Miao ₁

Affiliation

Seeing dots and AuNPs: Tetrahedral DNA nanoconjugates have been constructed from DNA, peptides, gold nanoparticles and carbon nanodots. Target telomerase and miRNA can achieve strand displacement of corresponding DNA strands with quenched fluorescence reporters. The as‐prepared biosystem is suitable for the simultaneous sensing and imaging of the dual biomarkers for diagnostics purposes.

中文翻译：

用于同时测量端粒酶活性和 miRNA 的四面体 DNA 纳米缀合物

观察点和金纳米粒子：四面体 DNA 纳米结合物已由 DNA、肽、金纳米粒子和碳纳米点构成。目标端粒酶和 miRNA 可以通过淬灭荧光报告基因实现相应 DNA 链的链置换。所制备的生物系统适合用于诊断目的的双生物标志物的同时传感和成像。

更新日期：2020-11-26

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