Imaging and Targeted Antibacterial Therapy Using Chimeric Antimicrobial Peptide Micelles,ACS Applied Materials & Interfaces

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Imaging and Targeted Antibacterial Therapy Using Chimeric Antimicrobial Peptide Micelles
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2020-11-25 , DOI: 10.1021/acsami.0c13083
Seong-Cheol Park ₁ , Changgon Ko , Hyejin Hyeon , Mi-Kyeong Jang ₁ , Dongwon Lee

Affiliation

Infectious diseases induced by multidrug-resistant bacteria are a challenging problem in medicine because of global rise in the drug resistance to pathogenic bacteria. Despite great efforts on the development of antibiotics and antimicrobial agents, there is still a great need to develop a strategy to early detect bacterial infections and eradicate bacteria effectively and simultaneously. The innate immune systems of various organisms produce antimicrobial peptides, which kill a broad range of bacteria with minimal cytotoxicity to mammalian cells. Therefore, antimicrobial peptides have recently attracted increasing attention as an alternative to conventional antibiotics in antibacterial medications. Here, we report a new family of antibacterial agents, which is formulated from self-assembly of a chimeric antimicrobial lipopeptide (DSPE-HnMc) and amphiphilic biodegradable polymers. HnMc micelles could effectively bind the bacterial membrane to kill a wide spectrum of bacteria and bacterial biofilms. In the studies of mouse models of drug-resistant bacterial infections, HnMc micelles could target bacterial infections with high specificity and also kill drug-resistant bacteria effectively, demonstrating the great potential of HnMc micelles as imaging and targeted antibacterial agents. These findings also provide new insight into the design of antimicrobial peptide-based nanomedicine for detection and treatment of bacterial infections.

中文翻译：

使用嵌合的抗菌肽胶束的成像和靶向抗菌治疗

由多药耐药菌引起的传染病在医学上是一个具有挑战性的问题，因为全球对病原菌的耐药性不断提高。尽管在开发抗生素和抗微生物剂方面付出了巨大的努力，但是仍然非常需要开发一种策略，以及早发现细菌感染并有效并同时消灭细菌。各种生物体的先天免疫系统会产生抗菌肽，从而杀死多种细菌，并且对哺乳动物细胞的细胞毒性极小。因此，作为抗菌药物中常规抗生素的替代品，抗菌肽最近已引起越来越多的关注。在这里，我们报告了一个新的抗菌剂家族，它是由嵌合抗菌脂肽（DSPE-HnMc）和两亲生物可降解聚合物自组装而成。HnMc胶束可以有效地结合细菌膜，杀死广泛的细菌和细菌生物膜。在对耐药细菌感染的小鼠模型的研究中，HnMc胶束可以高特异性地靶向细菌感染，还可以有效杀死耐药菌，证明了HnMc胶束作为成像和靶向抗菌剂的巨大潜力。这些发现也为检测和治疗细菌感染的基于抗菌肽的纳米药物的设计提供了新的见识。在对耐药细菌感染的小鼠模型的研究中，HnMc胶束可以高特异性地靶向细菌感染，还可以有效杀死耐药菌，证明了HnMc胶束作为成像和靶向抗菌剂的巨大潜力。这些发现也为检测和治疗细菌感染的基于抗菌肽的纳米药物的设计提供了新的见识。在对耐药细菌感染的小鼠模型的研究中，HnMc胶束可以高特异性地靶向细菌感染，还可以有效杀死耐药菌，证明了HnMc胶束作为成像和靶向抗菌剂的巨大潜力。这些发现也为用于检测和治疗细菌感染的基于抗菌肽的纳米药物的设计提供了新的见识。

更新日期：2020-12-09

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