Delicately Designed Cancer Cell Membrane-Camouflaged Nanoparticles for Targeted 19F MR/PA/FL Imaging-Guided Photothermal Therapy,ACS Applied Materials & Interfaces

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Delicately Designed Cancer Cell Membrane-Camouflaged Nanoparticles for Targeted 19F MR/PA/FL Imaging-Guided Photothermal Therapy
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2020-11-24 , DOI: 10.1021/acsami.0c13865
Sha Li _{1,

2} , Weiping Jiang _{1,

2} , Yaping Yuan _{1,

2} , Meiju Sui _{1,

2} , Yuqi Yang _{1,

2} , Liqun Huang _{1,

2} , Ling Jiang _{1,

2} , Maili Liu _{1,

2} , Shizhen Chen _{1,

2} , Xin Zhou _{1,

2}

Affiliation

Our exploration of multimodal nanoprobes aims to combine photoacoustic (PA) imaging, ¹⁹F magnetic resonance (MR), and fluorescence (FL) imaging, which offers complementary advantages such as high spatial resolution, unlimited penetration, and high sensitivity to enable more refined images for accurate tumor diagnoses. In this research, perfluorocarbons (PFCs) and indocyanine green (ICG) are encapsulated by poly(lactic-co-glycolic acid) (PLGA) for intravital ¹⁹F MR/FL/PA tri-modal imaging-guided photothermal therapy. Then, it is coated with an A549 cancer cell membrane (AM) to fabricate versatile theranostic nanoprobes (AM-PP@ICGNPs). After systemic administration, FLI reveals time-dependent tumor homing of NPs with high sensitivity, ¹⁹F MRI provides tumor localization of NPs without background signal interference, and PAI illustrates the detailed distribution of NPs inside the tumor with high spatial resolution. What is more, AM-PP@ICGNPs accumulated in the tumor area exhibit a prominent photothermal effect (48.4 °C) under near infrared (NIR) laser irradiation and realize an enhanced antitumor response in vivo. These benefits, in combination with the excellent biocompatibility, make AM-PP@ICGNPs a potential theranostic nanoagent for accurate tumor localization and ultimately achieve superior cancer therapy.

中文翻译：

精心设计的癌细胞膜伪装纳米颗粒，用于靶向¹⁹ F MR / PA / FL成像引导的光热疗法

我们对多峰纳米探针的探索旨在将光声（PA）成像，¹⁹ F磁共振（MR）和荧光（FL）成像相结合，从而提供互补的优势，例如高空间分辨率，无限穿透和高灵敏度，以实现更精细的图像用于准确的肿瘤诊断。在这项研究中，全氟化碳（PFC类）和吲哚花青绿（ICG）由聚（乳酸-包封的共-glycolic乙酸）（PLGA）对活体¹⁹佛塔斯奎先生/ FL / PA三峰成像引导光热治疗。然后，将其涂上A549癌细胞膜（AM）以制造通用的治疗学纳米探针（AM-PP @ ICGNPs）。全身性给药后，FLI显示了高敏感性NP的时间依赖性肿瘤归巢[ ^19]。F MRI提供了NPs的肿瘤定位，而没有背景信号干扰，而PAI以高空间分辨率说明了NPs在肿瘤内的详细分布。此外，在近红外（NIR）激光照射下，积聚在肿瘤区域中的AM-PP @ ICGNPs表现出显着的光热效应（48.4°C），并在体内实现增强的抗肿瘤反应。这些优点与出色的生物相容性相结合，使AM-PP @ ICGNPs成为潜在的治疗法纳米剂，可精确定位肿瘤并最终实现卓越的癌症治疗。

更新日期：2020-11-24

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