Pediatric Inflammatory Multisystem Syndrome temporarily associated with SARS-CoV-2 (PIMS-TS) or Multisystem Inflammatory Syndrome in Children (MIS-C) is a post COVID-19 multisystem inflammatory syndrome in children and adolescents <21 years of age. It is slowly emerging in India with clinical features overlapping with Kawasaki Disease (KD) and Toxic Shock Syndrome (TSS). Ten PIMS-TS cases admitted in a pediatric hospital between July and Sept 2020 were compared with 19 Kawasaki Disease (KD) patients’ data. The median age of PIMS-TS was 6 years (older to KD), 80% were males. PMS-TS cases had high inflammatory markers: CRP, ferritin, interleukin (IL)-6. Other distinct features were lymphopenia, hypoalbuminemia, and hyponatremia. Serial measurements of CRP showed high baseline values with subsequent decrease. NT-Pro BNP level was extremely elevated; suggestive of cardiac injury. All patients recovered. Laboratory features of PIMS-TS present a unique pattern of intense inflammation, and cardiac involvement that is different from features of pre COVID-19 KD. CRP remains a useful, inexpensive marker for PIMS-TS diagnosis and clinical progression.

中文翻译：

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暂时与儿童SARS-CoV-2（PIMS-TS）/儿童多系统炎症综合症（MIS-C）相关的儿童炎症多系统综合症的生物标志物概况

暂时与SARS-CoV-2（PIMS-TS）或儿童多系统炎症综合症（MIS-C）相关的小儿炎症多系统综合症是COVID-19后21岁以下儿童和青少年的多系统炎症综合症。它在印度正在慢慢出现，其临床特征与川崎病（KD）和毒性休克综合症（TSS）重叠。将2020年7月至2020年9月间在儿科医院收治的10例PIMS-TS患者与19例川崎病（KD）患者的数据进行比较。PIMS-TS的中位年龄为6岁（比KD大），男性占80％。PMS-TS病例具有较高的炎症标记：CRP，铁蛋白，白介素（IL）-6。其他明显特征是淋巴细胞减少症，低白蛋白血症和低钠血症。CRP的串行测量显示较高的基线值，随后降低。NT-Pro BNP水平极高；提示心脏损伤。所有患者均康复。PIMS-TS的实验室特征呈现出强烈的炎症和心脏受累的独特模式，这与COVID-19 KD之前的特征不同。CRP仍然是PIMS-TS诊断和临床进展的有用，廉价的标记物。