R134a was recognized as probably one of the most important refrigerants of the two past decades. Among the proposed alternative fluids, there are certainly isobutane (R600a) and R152a. This article presents about 200 new heat transfer coefficient and pressure drop data obtained during flow boiling of R152a and R600a inside a smooth copper tube having an internal diameter of 4 mm. Three saturation temperatures were considered for each refrigerant, from 5 °C to 20 °C. Furthermore, for each temperature studied, the heat flux was varied between 15 and 30 kW m⁻² and the refrigerant mass flux from 100 to 400 kg m⁻² s⁻¹. After presenting the new data, a critical comparison was proposed between the performance of these refrigerants and R134a. Finally, some classic correlations available in the literature have been implemented. The deviations between the calculated and experimental values were reported and commented.