In situ deposition of MOF-74(Cu) nanosheet arrays onto carbon cloth to fabricate a sensitive and selective electrocatalytic biosensor and its application for the determination of glucose in human serum,Microchimica Acta

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In situ deposition of MOF-74(Cu) nanosheet arrays onto carbon cloth to fabricate a sensitive and selective electrocatalytic biosensor and its application for the determination of glucose in human serum
Microchimica Acta ( IF 5.3 ) Pub Date : 2020-11-21 , DOI: 10.1007/s00604-020-04634-8
Shuisheng Hu _{1,

2} , Yuxia Lin ₁ , Jing Teng ₃ , Wing-Leung Wong ₂ , Bin Qiu ₁

Affiliation

A new electrocatalytic biosensor (MOF-74(Cu) NS-CC) based on the in situ deposition of MOF-74(Cu) nanosheet on carbon cloth via a bottom-up synthetic approach in a glass tube was developed. The electrocatalytic activity of the deposited MOF-74(Cu) NS was demonstrated in the oxidation of glucose to gluconate under alkaline conditions. The results revealed that the proposed method of in situ formation of MOF-74(Cu) NS onto a carbon cloth surface in a multi-layer solution is capable to generate a stable MOF-74(Cu) NS-CC electrode with excellent sensing performance. When the as-synthesized MOF-74(Cu) NS-CC was applied directly as the working electrode for glucose sensing, it showed much higher conductivity and redox activity than MOF-74(Cu) NS-GCE. With the potential applied at 0.55 V (vs. Ag/AgCl), this new electrocatalytic biosensor exhibits an excellent linear relationship between current density and concentration of glucose. Moreover, a wide linear range of detection (1.0 to 1000 μM) was observed. The limit of detection was found to be 0.41 μM (S/N = 3). The response sensitivity is 3.35 mA mM−1 cm−2 when the concentration of glucose is in the range 1–100 μM and 3.81 mA mM−1 cm−2 for the 100–1000 μM concentration range. This study provides a low-cost, easy to prepare, and reproducible methodology for the synthesis of highly redox-active nanomaterials based on the in situ formation of two-dimensional MOF-74(Cu) NS for the development of new electrocatalytic biosensors. Graphical abstract Graphical abstract

中文翻译：

MOF-74(Cu)纳米片阵列原位沉积在碳布上制备灵敏选择性电催化生物传感器及其在人血清中葡萄糖测定中的应用

开发了一种新的电催化生物传感器（MOF-74（Cu）NS-CC），该传感器基于在玻璃管中通过自下而上的合成方法在碳布上原位沉积 MOF-74（Cu）纳米片。沉积的 MOF-74(Cu) NS 的电催化活性在碱性条件下葡萄糖氧化为葡萄糖酸盐中得到证明。结果表明，所提出的在多层溶液中在碳布表面原位形成 MOF-74(Cu) NS 的方法能够产生稳定且具有优异传感性能的 MOF-74(Cu) NS-CC 电极. 当合成的 MOF-74(Cu) NS-CC 直接用作葡萄糖传感的工作电极时，它显示出比 MOF-74(Cu) NS-GCE 高得多的电导率和氧化还原活性。施加的电位为 0.55 V（相对于 Ag/AgCl），这种新型电催化生物传感器在电流密度和葡萄糖浓度之间表现出极好的线性关系。此外，还观察到了较宽的检测线性范围（1.0 至 1000 μM）。发现检测限为 0.41 μM (S/N = 3)。当葡萄糖浓度在 1-100 μM 范围内时，响应灵敏度为 3.35 mA mM-1 cm-2，而在 100-1000 μM 浓度范围内，响应灵敏度为 3.81 mA mM-1 cm-2。本研究为基于二维 MOF-74(Cu) NS 原位形成的高氧化还原活性纳米材料的合成提供了一种低成本、易于制备和可重复的方法，以开发新型电催化生物传感器。图形摘要图形摘要 0 到 1000 μM) 被观察到。发现检测限为 0.41 μM (S/N = 3)。当葡萄糖浓度在 1-100 μM 范围内时，响应灵敏度为 3.35 mA mM-1 cm-2，而在 100-1000 μM 浓度范围内，响应灵敏度为 3.81 mA mM-1 cm-2。本研究为基于二维 MOF-74(Cu) NS 原位形成的高氧化还原活性纳米材料的合成提供了一种低成本、易于制备和可重复的方法，以开发新型电催化生物传感器。图形摘要图形摘要 0 到 1000 μM) 被观察到。发现检测限为 0.41 μM (S/N = 3)。当葡萄糖浓度在 1-100 μM 范围内时，响应灵敏度为 3.35 mA mM-1 cm-2，而在 100-1000 μM 浓度范围内，响应灵敏度为 3.81 mA mM-1 cm-2。本研究为基于二维 MOF-74(Cu) NS 原位形成的高氧化还原活性纳米材料的合成提供了一种低成本、易于制备和可重复的方法，以开发新型电催化生物传感器。图形摘要图形摘要基于二维 MOF-74(Cu) NS 的原位形成合成高氧化还原活性纳米材料的可重复方法，用于开发新型电催化生物传感器。图形摘要图形摘要基于二维 MOF-74(Cu) NS 的原位形成合成高氧化还原活性纳米材料的可重复方法，用于开发新型电催化生物传感器。图形摘要图形摘要

更新日期：2020-11-21

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