Photoacoustic Cavitation‐Ignited Reactive Oxygen Species to Amplify Peroxynitrite Burst by Photosensitization‐Free Polymeric Nanocapsules,Angewandte Chemie International Edition

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Photoacoustic Cavitation‐Ignited Reactive Oxygen Species to Amplify Peroxynitrite Burst by Photosensitization‐Free Polymeric Nanocapsules
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-11-19 , DOI: 10.1002/anie.202013301
Zhixiong Wang _{1,

2} , Meixiao Zhan ₃ , Weijie Li _{1,

2} , Chengyan Chu _{1,

2} , Da Xing _{1,

2} , Siyu Lu ₄ , Xianglong Hu _{1,

2}

Affiliation

Photoacoustic (PA) technology can transform light energy into acoustic wave, which can be used for either imaging or therapy that depends on the power density of pulsed laser. Here, we report photosensitizer‐free polymeric nanocapsules loaded with nitric oxide (NO) donors, namely NO‐NCPs, formulated from NIR light‐absorbable amphiphilic polymers and a NO‐releasing donor, DETA NONOate. Controlled NO release and nanocapsule dissociation are achieved in acidic lysosomes of cancer cells. More importantly, upon pulsed laser irradiation, the PA cavitation can excite water to generate significant reactive oxygen species (ROS) such as superoxide radical (O₂^.−), which further spontaneously reacts with the in situ released NO to burst highly cytotoxic peroxynitrite (ONOO⁻) in cancer cells. The resultant ONOO⁻ generation greatly promotes mitochondrial damage and DNA fragmentation to initiate programmed cancer cell death. Apart from PA imaging, PA cavitation can intrinsically amplify reactive species via photosensitization‐free materials for promising disease theranostics.

中文翻译：

光声空化点燃的活性氧物种通过无光敏化的聚合物纳米胶囊扩大过氧亚硝酸盐的爆发。

光声（PA）技术可以将光能转换为声波，可以将其用于成像或治疗，具体取决于脉冲激光的功率密度。在这里，我们报道了由一氧化氮（NO）供体（即NO-NCP）组成的不含光敏剂的聚合物纳米胶囊，其由NIR吸光两亲聚合物和NO释放供体DETA NONOate配制而成。在癌细胞的酸性溶酶体中实现了受控的NO释放和纳米胶囊的解离。更重要的是，在脉冲激光照射下，PA空化会激发水以产生大量的活性氧（ROS），例如超氧自由基（O ₂^.-），它会进一步与原位释放的NO自发反应，从而炸裂具有高度细胞毒性的过氧亚硝酸盐（ ONOO ^-）在癌细胞中。将所得ONOO ^-代极大地促进线粒体损伤和DNA片段以引发程序性癌细胞死亡。除PA成像外，PA空化还可以通过无光敏材料本质上扩增反应物种，从而有望实现疾病治疗学。

更新日期：2020-11-19

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