Stimuli‐Responsive Nanocomposite Hydrogels for Biomedical Applications,Advanced Functional Materials

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Stimuli‐Responsive Nanocomposite Hydrogels for Biomedical Applications
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2020-11-18 , DOI: 10.1002/adfm.202005941
Pedro Lavrador ₁ , Marco R. Esteves ₁ , Vítor M. Gaspar ₁ , João F. Mano ₁

Affiliation

The complex tissue‐specific physiology that is orchestrated from the nano‐ to the macroscale, in conjugation with the dynamic biophysical/biochemical stimuli underlying biological processes, has inspired the design of sophisticated hydrogels and nanoparticle systems exhibiting stimuli‐responsive features. Recently, hydrogels and nanoparticles have been combined in advanced nanocomposite hybrid platforms expanding their range of biomedical applications. The ease and flexibility of attaining modular nanocomposite hydrogel constructs by selecting different classes of nanomaterials/hydrogels, or tuning nanoparticle‐hydrogel physicochemical interactions widely expands the range of attainable properties to levels beyond those of traditional platforms. This review showcases the intrinsic ability of hybrid constructs to react to external or internal/physiological stimuli in the scope of developing sophisticated and intelligent systems with application‐oriented features. Moreover, nanoparticle‐hydrogel platforms are overviewed in the context of encoding stimuli‐responsive cascades that recapitulate signaling interplays present in native biosystems. Collectively, recent breakthroughs in the design of stimuli‐responsive nanocomposite hydrogels improve their potential for operating as advanced systems in different biomedical applications that benefit from tailored single or multi‐responsiveness.

中文翻译：

用于生物医学的刺激响应性纳米复合水凝胶

从纳米级到宏观级的复杂组织特定生理学，再加上生物过程中潜在的动态生物物理/生化刺激物，激发了设计出具有刺激反应特性的复杂水凝胶和纳米颗粒系统的灵感。最近，水凝胶和纳米颗粒已经在先进的纳米复合材料混合平台中得到了组合，从而扩大了它们在生物医学领域的应用范围。通过选择不同类别的纳米材料/水凝胶，或调节纳米粒子-水凝胶的物理化学相互作用，获得模块化的纳米复合水凝胶结构的简便性和灵活性极大地将可达到的性能范围扩展到了传统平台以外的水平。这篇综述展示了在构建具有面向应用功能的复杂智能系统的过程中，混合结构对外部或内部/生理刺激做出反应的内在能力。此外，在编码刺激响应级联的背景下概述了纳米水凝胶平台，该级联概括了天然生物系统中存在的信号相互作用。总体而言，刺激响应性纳米复合水凝胶设计的最新突破提高了其在先进的系统中运行的潜力，这些技术可从定制的单响应或多响应性中受益于不同的生物医学应用。纳米粒子-水凝胶平台在编码刺激响应级联的背景下得到了概述，该级联概括了天然生物系统中存在的信号相互作用。总体而言，刺激响应性纳米复合水凝胶设计的最新突破提高了其在先进的系统中运行的潜力，这些技术可从定制的单响应或多响应性中受益于不同的生物医学应用。纳米粒子-水凝胶平台在编码刺激响应级联的背景下得到了概述，该级联概括了天然生物系统中存在的信号相互作用。总体而言，刺激响应性纳米复合水凝胶设计的最新突破提高了其在先进的系统中运行的潜力，这些技术可从定制的单响应或多响应性中受益于不同的生物医学应用。

更新日期：2020-11-18

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