A new approach to the synthesis of 2-(pyrimidin-2-yl)benzoic acids based on the ring contraction of the 2-carbamimidoylbenzoic acid [(2-amidinobenzoic) acid] with 1,3-dicarbonyl compounds and their synthetic equivalents has been developed. The intramolecular condensation of the obtained acids with 1,3-dielectrophiles proceeds with the formation of the 4,6-dihydropyrimido[2,1-a]isoindole-4,6-dione system, the pyrrolidone ring of which is easily opened under the action of weak nucleophiles. The reaction of 2-amidinobenzoic acid with chromones, which have an aryloxy group at 3-position does not stop at the step of pyrimidine ring formation and undergoes further spontaneous cyclization into 2-(benzo[4,5]furo[3,2-d]pyrimidin-2-yl)benzoic acids.

基于2-氨基甲酰氨基苯甲酸[（2-ami基苯甲酸）]与1,3-二羰基化合物及其合成等效物的环收缩，合成2-（嘧啶-2-基）苯甲酸的新方法已经得到。发达。所获得的酸与1，3-二亲电子分子的分子内缩合继续形成4，6-二氢嘧啶基[2，1 - a ]异吲哚-4，6-二酮体系，其吡咯烷酮环在环戊烷下容易打开。弱亲核试剂的作用。2-ami基苯甲酸与在3-位具有芳氧基的色酮的反应不会在嘧啶环形成的步骤中停止，并且会进一步自发环化为2-（苯并[4,5]呋喃[3,2- d ]嘧啶-2-基）苯甲酸。