合成纤维结膜肉芽肿的临床病理特征及手术结局,BMC Ophthalmology

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合成纤维结膜肉芽肿的临床病理特征及手术结局
BMC Ophthalmology ( IF 1.7 ) Pub Date : 2020-11-16 , DOI: 10.1186/s12886-020-01717-1
Zhang Chen , Tianyang Wang , Qintuo Pan , Zhaoliang Zhang , Zongduan Zhang

直到最近，合成纤维结膜肉芽肿（SFCG）鲜有报道，并且了解甚少。我们的研究旨在探讨手术切除后SFCG的临床特征，组织病理学特征，手术结果和预后。回顾性临床研究结果，组织病理学和免疫组化研究确定了18例SFCG。样品被常规处理并用H＆E染色。还对GMS，PAS，CD68和CK-pan进行了免疫组织化学染色。18名平均年龄为9.3±6.6岁的患者结膜上有白色至红色的嫩块。所有病变均已完全清除，无患者复发。从组织学上所有标本都显示出炎性肉芽组织，其中有大量的炎性细胞浸润和合成纤维的存在。免疫组织化学染色阳性的CD68，CK，GMS和PAS。合成纤维结膜肉芽肿是由合成外源性物质接种引起的异物感的罕见病灶。这些病变多为单侧，好发于结膜下穹for。SFCG的特征是大量炎性细胞浸润和合成纤维的存在。手术切除后再局部应用皮质类固醇激素已被临床证明有效。合成纤维结膜肉芽肿是由合成外源性物质接种引起的异物感的罕见病灶。这些病变多为单侧，好发于结膜下穹for。SFCG的特征是大量炎性细胞浸润和合成纤维的存在。手术切除后再局部应用皮质类固醇激素已被临床证明有效。合成纤维结膜肉芽肿是由合成外源性物质接种引起的异物感的罕见病灶。这些病变多为单侧，好发于结膜下穹for。SFCG的特征是大量炎性细胞浸润和合成纤维的存在。手术切除后再局部应用皮质类固醇激素已被临床证明有效。

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Clinicopathologic characteristics and surgical outcome of synthetic fiber conjunctival granuloma

Until recently, synthetic fiber conjunctival granuloma (SFCG) is rarely reported and has been poorly understood. Our study was to explore the clinical features, histopathologic characteristics, surgical outcomes, and prognosis of SFCG after surgical excision. Retrospective review of clinical findings, histopathological and immunohistochemical studies identified 18 cases of SFCG. Specimens were routinely processed and stained with H&E. Immunohistochemical stains for GMS, PAS, CD68 and CK-pan were also performed. Eighteen patients with an average age of 9.3 ± 6.6 years had a tender white to red mass on the conjunctiva. All the lesions were completely removed, and none of the patients relapsed. Histologically, all of the specimens revealed inflammatory granulation tissues with a large number of inflammatory cells infiltration and the presence of synthetic fibers. Immunohistochemical stains were positive for CD68, CK, GMS and PAS. Synthetic fiber conjunctival granuloma is an uncommon lesion with foreign body sensation caused by inoculation of synthetic exogenous materials. These lesions are mostly unilateral and occur in the inferior conjunctival fornix. SFCGs are characterized by a large number of inflammatory cells infiltration and the presence of synthetic fibers. Surgical excision followed by topical corticosteroids has been clinically proven to be effective.

更新日期：2020-11-16

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