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Degradable Silyl Ether–Containing Networks from Trifunctional Thiols and Acrylates
Macromolecules ( IF 5.1 ) Pub Date : 2020-11-16 , DOI: 10.1021/acs.macromol.0c01967 Caleb M. Bunton 1 , Zahra M. Bassampour 1 , Jennifer M. Boothby 2 , Ashanti N. Smith 1 , Joseph V. Rose 1 , Daphne M. Nguyen 1 , Taylor H. Ware 2 , Karl G. Csaky 3 , Alexander R. Lippert 1 , Nicolay V. Tsarevsky 1 , David Y. Son 1
Macromolecules ( IF 5.1 ) Pub Date : 2020-11-16 , DOI: 10.1021/acs.macromol.0c01967 Caleb M. Bunton 1 , Zahra M. Bassampour 1 , Jennifer M. Boothby 2 , Ashanti N. Smith 1 , Joseph V. Rose 1 , Daphne M. Nguyen 1 , Taylor H. Ware 2 , Karl G. Csaky 3 , Alexander R. Lippert 1 , Nicolay V. Tsarevsky 1 , David Y. Son 1
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The purpose of this study was the synthesis of novel degradable polymer-based devices capable of releasing an encapsulated agent in a controlled manner with specific interest for use as drug delivery materials. Base-catalyzed thiol Michael additions between trithiols and triacrylates containing silyl ether groups were exploited to prepare a series of degradable cross-linked networks. Disodium fluorescein was loaded as a hydrophilic drug surrogate inside the networks, and the degradation of the networks and the release of dye were monitored. The networks were characterized by Fourier transform infrared spectroscopy, and their thermal and mechanical properties were investigated through thermogravimetric analysis and dynamic mechanical analysis. The effects of the monomer structure on degradation, release behavior, and thermal properties were investigated. The networks prepared from more sterically hindered silyl ether monomers exhibited decreased rates of degradation and correspondingly slower release of encapsulated disodium fluorescein dye. The results suggest that the characteristics of the networks can be fine-tuned by manipulation of the group attached to the Si atom in the silyl ether monomers.
中文翻译：
三官能硫醇和丙烯酸酯可降解的含甲硅烷基醚的网络
这项研究的目的是合成新型可降解的基于聚合物的装置，该装置能够以受控的方式释放被包封的药物，并特别关注用作药物输送材料。利用三甲硫醇和含有甲硅烷基醚基的三丙烯酸酯之间的碱催化硫醇迈克尔加成反应制备了一系列可降解的交联网络。将荧光素二钠作为亲水性药物替代物装载到网络内部，并监测网络的降解和染料的释放。通过傅立叶变换红外光谱对网络进行表征，并通过热重分析和动态力学分析研究其热和机械性能。单体结构对降解，释放行为，和热性能进行了研究。由空间位阻较大的甲硅烷基醚单体制备的网络表现出降低的降解速率，并相应地降低了封装的荧光素二钠染料的释放。结果表明，可以通过操纵与甲硅烷基醚单体中的Si原子相连的基团来微调网络的特性。
更新日期：2020-11-25
中文翻译：
三官能硫醇和丙烯酸酯可降解的含甲硅烷基醚的网络
这项研究的目的是合成新型可降解的基于聚合物的装置，该装置能够以受控的方式释放被包封的药物，并特别关注用作药物输送材料。利用三甲硫醇和含有甲硅烷基醚基的三丙烯酸酯之间的碱催化硫醇迈克尔加成反应制备了一系列可降解的交联网络。将荧光素二钠作为亲水性药物替代物装载到网络内部，并监测网络的降解和染料的释放。通过傅立叶变换红外光谱对网络进行表征，并通过热重分析和动态力学分析研究其热和机械性能。单体结构对降解，释放行为，和热性能进行了研究。由空间位阻较大的甲硅烷基醚单体制备的网络表现出降低的降解速率，并相应地降低了封装的荧光素二钠染料的释放。结果表明，可以通过操纵与甲硅烷基醚单体中的Si原子相连的基团来微调网络的特性。
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