Applied Microbiology and Biotechnology ( IF 3.9 ) Pub Date : 2020-10-17 , DOI: 10.1007/s00253-020-10949-6 Xu Tan , Wei Song , Xiulai Chen , Liming Liu , Jing Wu
l-Tyrosine is an aromatic, polar, non-essential amino acid that contains a highly reactive α-amino, α-carboxyl, and phenolic hydroxyl group. Derivatization of these functional groups can produce chemicals, such as l-3,4-dihydroxyphenylalanine, tyramine, 4-hydroxyphenylpyruvic acid, and benzylisoquinoline alkaloids, which are widely employed in the pharmaceutical, food, and cosmetics industries. In this review, we summarize typical l-tyrosine derivatizations catalyzed by enzymatic biocatalysts, as well as the strategies and challenges associated with their production processes. Finally, we discuss future perspectives pertaining to the enzymatic production of l-tyrosine derivatives.
Key points
• Summary of recent advances in enzyme-catalyzed l-tyrosine derivatization.
• Highlights of relevant strategies involved in l-tyrosine derivatives biosynthesis.
• Future perspectives on industrial applications of l-tyrosine derivatization.
中文翻译:
酪氨酸生物催化衍生化的最新进展
1-酪氨酸是芳香族,极性非必需氨基酸,包含高反应性的α-氨基,α-羧基和酚羟基。这些官能团的衍生化可以产生化学物质,如升-3,4-二羟基苯丙氨酸,酪胺,4-羟苯丙酮酸,和苄基异生物碱,其在药物,食品和化妆品工业中广泛使用。在这次审查中,我们总结典型升酶法生物催化剂催化酪氨酸衍生,以及与生产过程相关的策略和挑战。最后,我们讨论了有关酶催化生产1-酪氨酸衍生物的未来观点。
关键点
•酶催化的1-酪氨酸衍生化的最新进展概述。
•涉及1-酪氨酸衍生物生物合成的相关策略的重点。
•对工业应用的未来前景升酪氨酸衍生。