<br>CBD 分子靶点和信号通路的多样性,Pharmacology Research & Perspectives

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CBD 分子靶点和信号通路的多样性
Pharmacology Research & Perspectives ( IF 2.9 ) Pub Date : 2020-11-09 , DOI: 10.1002/prp2.682
Douglas L de Almeida _{1,

2} , Lakshmi A Devi ₁

Affiliation

大麻二酚 (CBD) 是大麻植物中第二丰富的成分，已知具有与 Δ ⁹ -四氢大麻酚 (THC) 不同的作用。许多研究 CBD 对行为影响的研究得出的结论是，它缺乏 THC 带来的拟精神病作用。然而，CBD 对焦虑、炎症、神经性疼痛和癫痫等多种疾病具有广泛的影响。目前认为 CBD 涉及不同的靶点，因此 CBD 的作用被认为是由于多种分子作用机制。一组被广泛接受的靶标包括 GPCR 和离子通道，其中血清素 5-HT _1A受体和瞬时受体电位阳离子通道 TRPV1 通道是两个主要靶标。 CBD 也被认为可以靶向 G 蛋白偶联受体 (GPCR)，例如大麻素和阿片受体。其他研究表明额外的 GPCR 和离子通道可以作为 CBD 的靶标。目前，CBD的临床疗效尚不完全清楚。来自随机临床试验、体外和体内模型以及现实世界观察的证据支持使用 CBD 作为焦虑、神经病变和许多其他疾病的药物治疗选择。因此，了解该领域与 CBD 目标相关的现状非常有意义，因此，在这篇综述中，我们纳入了强调这些主要目标的最新研究结果。

"点击查看英文标题和摘要"

Diversity of molecular targets and signaling pathways for CBD

Cannabidiol (CBD) is the second most abundant component of the Cannabis plant and is known to have effects distinct from Δ⁹‐tetrahydrocannabinol (THC). Many studies that examined the behavioral effects of CBD concluded that it lacks the psychotomimetic effects attributed to THC. However, CBD was shown to have a broad spectrum of effects on several conditions such as anxiety, inflammation, neuropathic pain, and epilepsy. It is currently thought that CBD engages different targets and hence CBD’s effects are thought to be due to multiple molecular mechanisms of action. A well‐accepted set of targets include GPCRs and ion channels, with the serotonin 5‐HT_1A receptor and the transient receptor potential cation channel TRPV1 channel being the two main targets. CBD has also been thought to target G protein‐coupled receptors (GPCRs) such as cannabinoid and opioid receptors. Other studies have suggested a role for additional GPCRs and ion channels as targets of CBD. Currently, the clinical efficacy of CBD is not completely understood. Evidence derived from randomized clinical trials, in vitro and in vivo models and real‐world observations support the use of CBD as a drug treatment option for anxiety, neuropathy, and many other conditions. Hence an understanding of the current status of the field as it relates to the targets for CBD is of great interest so, in this review, we include findings from recent studies that highlight these main targets.

更新日期：2020-11-12

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