Location of a single histidine within peptide carriers increases mRNA delivery,The Journal of Gene Medicine

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Location of a single histidine within peptide carriers increases mRNA delivery
The Journal of Gene Medicine ( IF 3.2 ) Pub Date : 2020-11-10 , DOI: 10.1002/jgm.3295
Jiaxi He ₁ , Songhui Xu ₁ , Qixin Leng ₁ , A James Mixson ₁

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Previously, we determined that four‐branched histidine‐lysine (HK) peptides were effective carriers of plasmids and small interfering RNA. In the present study, we compared several branched HK carriers and, in particular, two closely‐related H3K4b and H3K(+H)4b peptides for their ability as carriers of mRNA. The H3K(+H)4b peptide differed from its parent analogue, H3K4b, by only a single histidine in each branch.

中文翻译：

肽载体内单个组氨酸的位置增加了 mRNA 的传递

此前，我们确定四支组氨酸-赖氨酸 (HK) 肽是质粒和小干扰 RNA 的有效载体。在本研究中，我们比较了几种分支的 HK 载体，特别是两种密切相关的 H3K4b 和 H3K(+H)4b 肽作为 mRNA 载体的能力。H3K(+H)4b 肽与其亲本类似物H3K4b 的不同之处在于每个分支中只有一个组氨酸。

更新日期：2020-11-10

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