A Reactive Oxygen Species Scavenging and O2 Generating Injectable Hydrogel for Myocardial Infarction Treatment In vivo,Small

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A Reactive Oxygen Species Scavenging and O2 Generating Injectable Hydrogel for Myocardial Infarction Treatment In vivo
Small ( IF 13.0 ) Pub Date : 2020-11-09 , DOI: 10.1002/smll.202005038
Jie Ding ₁ , Yuejun Yao ₁ , Jiawei Li ₁ , Yiyuan Duan _{1,

2} , Jayachandra Reddy Nakkala _{1,

2} , Xue Feng ₁ , Wangbei Cao ₁ , Yingchao Wang ₁ , Liangjie Hong ₁ , Liyin Shen ₁ , Zhengwei Mao ₁ , Yang Zhu ₁ , Changyou Gao _{1,

2}

Affiliation

The excessive reactive oxygen species (ROS) and hypoxia deteriorate the inflammation‐related diseases such as myocardial infarction (MI), and thereby deter the normal tissue repair and recovery and further lead to severe fibrosis and malfunction of tissues and organs. In particular, the MI has become one of the leading causes of death nowadays. In this study, a novel type of injectable hydrogel with dual functions of ROS scavenging and O₂ generating is fabricated for MI treatment in vivo. The hydrogel is formed within 3 s from the synthetic ROS‐cleavable hyperbranched polymers and methacrylate hyaluronic acid (HA‐MA) under UV‐irradiation. Addition of biocompatible and applicable catalase in vivo enables the further transition of H₂O₂, a major type of ROS, to O₂ and H₂O. Results of rat MI model demonstrate that this hydrogel can significantly remove excessive ROS, inhibit cell apoptosis, increase M2/M1 macrophage ratio, promote angiogenesis, reduce infarcted area, and improve cardiac functions. With the appropriate degradation rate, simple structure and composition without cell seeding, and very excellent MI therapeutic effect, this ROS scavenging and O₂ generating hydrogel has a great promise to be applied clinically.

中文翻译：

一种活性氧清除和O2生成的可注射水凝胶，用于体内心肌梗塞治疗

过量的活性氧（ROS）和缺氧会恶化与炎症有关的疾病，例如心肌梗塞（MI），从而阻碍正常的组织修复和恢复，并进一步导致严重的纤维化和组织器官的功能异常。特别是，MI已成为当今导致死亡的主要原因之一。在这项研究中，一种新型的可注射的水凝胶具有ROS清除和O ₂生成的双重功能，可用于体内MI治疗。水凝胶是在紫外线照射下于3 s内由合成的ROS可裂解的超支化聚合物和甲基丙烯酸透明质酸（HA-MA）形成的。在体内添加生物相容性和适用的过氧化氢酶可实现H ₂ O ₂的进一步转变ROS是O ₂和H ₂ O的主要类型。大鼠MI模型的结果表明，这种水凝胶可以显着去除过量的ROS，抑制细胞凋亡，增加M2 / M1巨噬细胞比例，促进血管生成，减少梗塞面积并改善心脏功能。具有适当的降解速率，简单的结构和组成而无需细胞接种，并且具有非常优异的MI治疗效果，这种清除ROS和产生O _2的水凝胶具有广阔的临床应用前景。

更新日期：2020-12-03

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