Nitroimidazoles based compounds remain a hot topic of research in medicinal chemistry due to their numerous biological activities. Moreover, many clinical candidates based on this chemical core have been reported to be valuable in the treatment of human diseases. Metronidazole (MTZ) derived conjugates demonstrated a potential application in medicinal chemistry research over the last decade. In this review, we summarize the synthesis, key structure-activity-relationship (SAR) and associated biological activities such as antimicrobial, anticancer, antidiabetic, anti-inflammatory, anti-HIV and anti-parasitic (Anti-trichomonas, antileishmanial, antiamoebic and anti-giardial) of explored MTZ-conjugates. The molecular docking analysis is also presented simultaneously, which will assist in developing an understanding towards designing of new MTZ-conjugates for target-based drug discovery against multiple disease areas.

由于基于硝基咪唑的化合物具有多种生物活性，因此它们仍是药物化学研究的热点。此外，据报道许多基于该化学核心的临床候选物在人类疾病的治疗中是有价值的。过去十年间，甲硝唑（MTZ）衍生的结合物在药物化学研究中显示出潜在的应用。在这篇综述中，我们总结了合成，关键结构-活性-关系（SAR）和相关的生物学活性，例如抗微生物剂，抗癌剂，抗糖尿病药，抗炎药，抗HIV药和抗寄生虫药（抗毛滴虫，抗衰老，抗阿米巴和的MTT共轭物。分子对接分析也同时进行，