子宫切除术后10余年子宫内膜癌全身复发2例报告并文献复习,Journal of the Egyptian National Cancer Institute

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子宫切除术后10余年子宫内膜癌全身复发2例报告并文献复习
Journal of the Egyptian National Cancer Institute ( IF 2.1 ) Pub Date : 2020-11-02 , DOI: 10.1186/s43046-020-00052-2
Leonardo Muratori ₁ , Paola Sperone ₁ , Gabriella Gorzegno ₁ , Anna La Salvia ₂ , Giorgio Vittorio Scagliotti ₁

Affiliation

子宫内膜癌是发达国家最常见的女性癌症之一。疾病分期与根治性治疗后疾病复发的风险相关。通常，疾病复发的风险在局部根治性治疗后 3 年达到峰值，然后随着时间的推移而降低，因此晚期复发（即从第 5 年开始）非常罕见。在这里，我们报告了两例子宫内膜癌女性患者，她们在根治性治疗后超过 15 年出现疾病复发。对文献的回顾揭示了其他 7 篇关于子宫内膜癌复发的女性在根治性治疗后 10 年以上的报告。病例报告 1 是一名 56 岁的子宫内膜样癌女性，她于 1998 年接受了双侧输卵管卵巢切除术的子宫切除术。她于 2014 年肺部复发，16 年从根治性手术。病例报告 2，一名 75 岁女性，患有子宫内膜样癌，接受子宫切除术、双侧输卵管卵巢切除术和辅助放疗。2019 年，即根治治疗 22 年后，发现肺部疾病复发。虽然指南不支持手术后 5 年以上的肿瘤学随访，但肿瘤学家在鉴别诊断中应考虑子宫内膜癌的晚期复发，以鉴别起源和既往病史不明的转移灶。

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Systemic recurrence of endometrial cancer more than 10 years after hysterectomy: a report of two cases and a brief review of the literature

Endometrial carcinoma is one of the most common female cancers in developed countries. Disease stage is associated with the risk of disease relapse after radical treatment. Typically, the risk of disease relapse peaks at 3 years from local radical treatment and then diminishes over time, so that late relapses (i.e., from year 5 afterward) are extremely infrequent. Here, we report two cases of women with endometrial cancer who developed a disease relapse more than 15 years after radical treatment. A review of the literature revealed other seven reports of women with relapse from endometrial cancer occurring more than 10 years after radical treatment. Case report 1 is a 56-year-old woman with an endometrioid cancer who underwent a hysterectomy with bilateral salpingo-oophorectomy in 1998. She relapsed in the lung in 2014, 16 years from radical surgery. Case report 2, a 75-year-old woman, with an endometrioid cancer, was treated by hysterectomy with bilateral salpingo-oophorectomy and adjuvant radiotherapy. The disease relapse in the lung was detected in 2019, 22 years from radical treatment. Although guidelines do not support oncological follow-up beyond 5 years from surgery, oncologists should consider late recurrence of endometrial carcinoma in the differential diagnosis of women presenting with metastases of uncertain origin and prior history of this disease.

更新日期：2020-11-02

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